Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 12/20 | 0.63 |
| ▸ | PRKCI | P41743 | 1/20 | 0.60 |
| ▸ | ATR | Q13535 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | PRKDC | P78527 | 1/20 | 0.54 |
| ▸ | XPO1 | O14980 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16465324 | 0.86 | PRKCI (0.52) | PTPN11PRKCIATRALDH1A1LMNA | |
| SCHEMBL6582057 | 0.83 | PTPN11 (0.59) | PTPN11PRKCIATRALDH1A1LMNA | |
| SCHEMBL4559784 | 0.82 | PTPN11 (0.48) | PTPN11PRKCIATRALDH1A1LMNA | |
| SCHEMBL4559143 | 0.82 | KMT2A (0.51) | PTPN11PRKCIATRALDH1A1LMNA | |
| SCHEMBL4559593 | 0.81 | PTPN11 (0.56) | PTPN11PRKCIATRALDH1A1LMNA | |
| SCHEMBL22573622 | 0.80 | PTPN11 (0.52) | PTPN11PRKCIATRALDH1A1LMNA | |
| SCHEMBL22573544 | 0.79 | LMNA (0.64) | PTPN11PRKCIATRALDH1A1LMNA | |
| SCHEMBL22573444 | 0.79 | PRKCI (0.58) | PTPN11PRKCIATRALDH1A1LMNA | |
| SCHEMBL4560198 | 0.78 | KDM4E (0.65) | PRKCIATRALDH1A1KDM4E | |
| SCHEMBL22573364 | 0.78 | ATR (0.61) | PTPN11PRKCIATRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0012361-A1 | Amino-pyrimidine-carbanilides, process for their preparation, medicines containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-06-25 | — | — | EP | claimed |
| EP-0012361-B1 | Amino-pyrimidine-carbanilides, process for their preparation, medicines containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-06-30 | — | — | EP | disclosed |
| US-4285946-A | ANOREXIGENIC AGENTS; TREATING DISTURBANCES OF THE METABOLISM OF LIPIDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-08-25 | — | — | US | disclosed |
| EP-0012361-A1 | Amino-pyrimidine-carbanilides, process for their preparation, medicines containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-06-25 | — | — | EP | disclosed |
| EP-0012361-A1 | Amino-pyrimidine-carbanilides, process for their preparation, medicines containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-06-25 | — | — | EP | disclosed |