SCHEMBL11299031

SCHEMBL11299031

CCOC(=O)c1c(C)cc(C(=O)OC)c(N)c1C

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.49
MAPT P10636 3/20 0.49
KMT2A Q03164 2/20 0.49
MEN1 O00255 1/20 0.49
HPGD P15428 4/20 0.47
CYP3A4 P08684 3/20 0.47
SMN1; SMN2 Q16637 2/20 0.46
TDP1 Q9NUW8 1/20 0.46
KDM4E B2RXH2 2/20 0.46
ADORA1 P30542 1/20 0.45
PDE1A P54750 1/20 0.45
PDE1B Q01064 1/20 0.45
PDE3B Q13370 1/20 0.45
PDE1C Q14123 1/20 0.45
PDE3A Q14432 1/20 0.45
GAA P10253 2/20 0.44
NR1H2 P55055 1/20 0.42
NR1H3 Q13133 1/20 0.42
POLB P06746 1/20 0.42
NPC1 O15118 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11378236 0.86 CYP3A4 (0.47) ALDH1A1MAPTKMT2AMEN1HPGD
SCHEMBL844149 0.84 CYP3A4 (0.49) ALDH1A1MAPTKMT2AMEN1HPGD
SCHEMBL5988684 0.82 ALDH1A1 (0.54) ALDH1A1MAPTKMT2AMEN1HPGD
SCHEMBL844171 0.80 ALDH1A1 (0.50) ALDH1A1MAPTKMT2AMEN1HPGD
SCHEMBL844688 0.79 CYP3A4 (0.47) ALDH1A1MAPTKMT2AMEN1HPGD
SCHEMBL7322393 0.79 KDM4E (0.50) ALDH1A1MAPTHPGDKDM4EGAA
SCHEMBL11374117 0.77 GRM6 (0.46) ALDH1A1MAPTKMT2AMEN1HPGD
SCHEMBL10935815 0.76 CYP3A4 (0.51) ALDH1A1MAPTKMT2AMEN1HPGD
SCHEMBL7553261 0.75 CYP3A4 (0.50) ALDH1A1MAPTKMT2AMEN1HPGD
SCHEMBL4630661 0.75 CYP3A4 (0.50) ALDH1A1MAPTKMT2AMEN1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-56051461-A None JP disclosed
US-4276295-A VASODILATORS, HYPOTENSIVE, ANTIATHEROSCLEROTIC Ishikawa, Masayuki (JP) 1981-06-30 US disclosed
JP-S5651461-A NOVEL 3-PHENYL-4-QUINAZOLONE DERIVATIVE ISHIKAWA MASAYUKI 1981-05-09 JP disclosed