Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 5/20 | 0.62 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.62 |
| ▸ | PTGER3 | P43115 | 4/20 | 0.62 |
| ▸ | PTGIR | P43119 | 2/20 | 0.62 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | PTGFR | P43088 | 2/20 | 0.62 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.62 |
| ▸ | ESR1 | P03372 | 1/20 | 0.62 |
| ▸ | PGR | P06401 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.62 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11306606 | 1.00 | PTGER4 (0.62) | PTGER4PTGER2PTGER3PTGIRPTGER1 | |
| SCHEMBL11378070 | 1.00 | PTGER4 (0.62) | PTGER4PTGER2PTGER3PTGIRPTGER1 | |
| SCHEMBL11546236 | 0.86 | PTGER4 (0.81) | PTGER4PTGER2PTGER3PTGIRPTGER1 | |
| SCHEMBL11775424 | 0.86 | PTGER4 (0.81) | PTGER4PTGER2PTGER3PTGIRPTGER1 | |
| SCHEMBL11546235 | 0.86 | PTGER4 (0.81) | PTGER4PTGER2PTGER3PTGIRPTGER1 | |
| SCHEMBL11776804 | 0.86 | PTGER4 (0.81) | PTGER4PTGER2PTGER3PTGIRPTGER1 | |
| SCHEMBL11371904 | 0.84 | PTGER4 (0.55) | PTGER4PTGER2PTGER3PTGIRPTGER1 | |
| SCHEMBL11048212 | 0.84 | PTGER4 (0.55) | PTGER4PTGER2PTGER3PTGIRPTGER1 | |
| SCHEMBL11367214 | 0.84 | PTGER4 (0.55) | PTGER4PTGER2PTGER3PTGIRPTGER1 | |
| SCHEMBL11365404 | 0.82 | PTGER4 (0.58) | PTGER4PTGER2PTGER3PTGIRPTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4306078-A | 16-Substituted prostaglandins | HOFFMANN-LA ROCHE INC. (US) | 1981-12-15 | — | — | US | disclosed |
| US-4260818-A | ANTISECRETORY, ANTIULCER, HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1981-04-07 | — | — | US | disclosed |
| US-4256911-A | TRIFLUOROMETHYL-CARBOXY ESTERS | HOFFMANN-LA ROCHE INC. (US) | 1981-03-17 | — | — | US | disclosed |
| US-4237276-A | CARDIOVASCULAR AGENTS, INDUCTION OF LABOR, TERMINATION OF PREGNANCY | HOFFMANN-LA ROCHE INC. (US) | 1980-12-02 | — | — | US | disclosed |
| US-4212993-A | 11-ALKYL-13-SATURATED-15-KETO-16-FLUORO, -ALKYL OR -TRIFLUOROMETHYL DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 1980-07-15 | — | — | US | disclosed |
| US-4211724-A | ENANTIOMORPHS, INTERMEDIATE AMIDES WITH ASSYMETRIC CARBON ATOM | HOFFMAN-LA ROCHE INC. (US) | 1980-07-08 | — | — | US | disclosed |
| US-4204074-A | ANTISECRETORY, HYPOTENSIVE, ANTIULCER | HOFFMANN-LA ROCHE INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4190587-A | PROSTAGLANDINS | HOFFMANN-LA ROCHE INC. (US) | 1980-02-26 | — | — | US | disclosed |
| US-4187381-A | CARDIOVASCULAR AGENTS; OXYTOCICS | HOFFMANN-LA ROCHE INC. (US) | 1980-02-05 | — | — | US | disclosed |
| US-4163016-A | ANTISECRETORY AGENTS, HYPOTENSIVE AGENTS, ANTIULCER AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1979-07-31 | — | — | US | disclosed |
| US-4112225-A | 16-CF3 prostaglandins | HOFFMAN-LA ROCHE INC. (US) | 1978-09-05 | — | — | US | disclosed |