Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11301960 | 0.88 | TSHR (0.50) | TSHRMEN1KMT2ANPSR1POLB | |
| SCHEMBL30569971 | 0.80 | NPSR1 (0.48) | TSHRMEN1KMT2ANPSR1MAPT | |
| SCHEMBL21753945 | 0.80 | NPSR1 (0.48) | TSHRMEN1KMT2ANPSR1MAPT | |
| SCHEMBL11299044 | 0.79 | ALDH1A1 (0.46) | TSHRMEN1KMT2ANPSR1POLB | |
| SCHEMBL11671063 | 0.78 | TSHR (0.68) | TSHRMEN1KMT2ANPSR1POLB | |
| Hydrochloric Acid SCHEMBL11301605 | 0.78 | ALDH1A1 (0.45) | TSHRMEN1KMT2ANPSR1POLB | |
| SCHEMBL10156527 | 0.77 | HPGD (0.66) | TSHRMEN1KMT2ATDP1MAPT | |
| SCHEMBL11698215 | 0.72 | MAPT (0.66) | TSHRTDP1MAPTPOLBHPGD | |
| SCHEMBL1638498 | 0.72 | TDP1 (0.56) | TSHRMEN1KMT2ATDP1MAPT | |
| SCHEMBL11670786 | 0.72 | NPSR1 (0.70) | TSHRMEN1KMT2ANPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098070-A1 | QUINOLINE DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |