Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 8/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 7/20 | 0.49 |
| ▸ | BRAF | P15056 | 5/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10324514 | 0.90 | DYRK1A (0.49) | DYRK1ADYRK1BROCK2TP53NPC1 | |
| SCHEMBL10323582 | 0.90 | DYRK1A (0.48) | DYRK1ADYRK1BBRAFTP53 | |
| SCHEMBL10323240 | 0.87 | DYRK1A (0.47) | DYRK1ADYRK1BBRAFTP53 | |
| SCHEMBL11304265 | 0.85 | DYRK1A (0.69) | DYRK1ADYRK1B | |
| SCHEMBL10324084 | 0.79 | DYRK1A (0.48) | DYRK1ADYRK1BTP53 | |
| SCHEMBL10446533 | 0.78 | DYRK1A (0.71) | DYRK1ADYRK1B | |
| SCHEMBL10323719 | 0.77 | DYRK1A (0.49) | DYRK1ADYRK1BROCK2NPC1 | |
| SCHEMBL10324491 | 0.76 | DYRK1A (0.70) | DYRK1ADYRK1B | |
| SCHEMBL10323580 | 0.76 | DYRK1A (0.67) | DYRK1ADYRK1B | |
| SCHEMBL10324510 | 0.76 | DYRK1A (0.68) | DYRK1ADYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098065-A1 | PYRIDO PYRIMIDINES FOR USE AS DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |