Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR3 | O15455 | 1/20 | 0.76 |
| ▸ | OGG1 | O15527 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 6/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.58 |
| ▸ | PRNP | P04156 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11951263 | 1.00 | TLR3 (0.76) | TLR3OGG1RXFP1NPSR1PRNP | |
| SCHEMBL11951514 | 1.00 | TLR3 (0.76) | TLR3OGG1RXFP1NPSR1PRNP | |
| SCHEMBL11498990 | 0.88 | TLR3 (0.80) | TLR3RXFP1NPSR1PRNPALDH1A1 | |
| SCHEMBL11498991 | 0.88 | TLR3 (0.80) | TLR3RXFP1NPSR1PRNPALDH1A1 | |
| SCHEMBL11950554 | 0.88 | TLR3 (0.80) | TLR3RXFP1NPSR1PRNPALDH1A1 | |
| SCHEMBL11300435 | 0.86 | TLR3 (0.84) | TLR3RXFP1NPSR1PRNPALDH1A1 | |
| SCHEMBL11951271 | 0.86 | TLR3 (0.84) | TLR3RXFP1NPSR1PRNPALDH1A1 | |
| SCHEMBL11500750 | 0.86 | TLR3 (0.84) | TLR3RXFP1NPSR1PRNPALDH1A1 | |
| SCHEMBL11951244 | 0.86 | TLR3 (1.00) | TLR3RXFP1NPSR1PRNPALDH1A1 | |
| SCHEMBL11951242 | 0.86 | TLR3 (1.00) | TLR3RXFP1NPSR1PRNPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025030019-A1 | TARGETING TLR3 FOR TREATMENT OF HEMATOPOIETIC STEM CELL PROLIFERATION-ASSOCIATED DISEASES OR DISORDERS | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2025-02-06 | — | — | WO | disclosed |
| US-9409880-B2 | Modulators of TLR3/dsRNA complex and uses thereof | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2016-08-09 | — | — | US | disclosed |
| EP-2665708-A2 | MODULATORS OF TLR3/DSRNA COMPLEX AND USES THEREOF | The Regents of the University of Colorado, A Body Corporate (US) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012099785-A2 | MODULATORS OF TLR3/DSRNA COMPLEX AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2012-07-26 | — | — | WO | disclosed |