Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Carbenicillin Indanyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | RECQL | P46063 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | TEK | Q02763 | 1/20 | 0.54 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | CCKBR | P32239 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 4/20 | 0.47 |
| ▸ | RARB | P10826 | 1/20 | 0.47 |
| ▸ | RARG | P13631 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Carbenicillin Indanyl SCHEMBL11307350 | 1.00 | KDM4E (0.54) | KDM4ERECQLTDP1MEN1KMT2A | |
| Carbenicillin Indanyl SCHEMBL4936924 | 0.95 | KDM4E (0.57) | KDM4ERECQLTDP1MEN1KMT2A | |
| Carbenicillin Indanyl SCHEMBL29592774 | 0.95 | KDM4E (0.57) | KDM4ERECQLTDP1MEN1KMT2A | |
| Carbenicillin Indanyl SCHEMBL11309244 | 0.95 | KDM4E (0.57) | KDM4ERECQLTDP1MEN1KMT2A | |
| Carbenicillin Indanyl SCHEMBL10741454 | 0.95 | KDM4E (0.57) | KDM4ERECQLTDP1MEN1KMT2A | |
| Carbenicillin Indanyl SCHEMBL33857 | 0.95 | KDM4E (0.57) | KDM4ERECQLTDP1MEN1KMT2A | |
| Carbenicillin Indanyl SCHEMBL33855 | 0.95 | KDM4E (0.57) | KDM4ERECQLTDP1MEN1KMT2A | |
| Carbenicillin Indanyl SCHEMBL11311104 | 0.94 | KDM4E (0.56) | KDM4ERECQLTDP1MEN1KMT2A | |
| Carbenicillin Indanyl SCHEMBL954017 | 0.94 | KDM4E (0.56) | KDM4ERECQLTDP1MEN1KMT2A | |
| Carbenicillin Indanyl SCHEMBL22818119 | 0.94 | KDM4E (0.56) | KDM4ERECQLTDP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4304717-A | Process for the preparation of reactive penicillanic acid and cephalosporanic acid derivatives | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT (HU) | 1981-12-08 | — | — | US | disclosed |
| US-4171303-A | Process for the preparation of reactive penicillanic acid and cephalosporanic acid derivatives | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1979-10-16 | — | — | US | disclosed |