SCHEMBL11308506

SCHEMBL11308506

Cc1cc(=O)cc(C)n1-c1ccc(Cl)c(Cl)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.67
NOTUM Q6P988 1/20 0.57
ALDH1A1 P00352 3/20 0.54
HTT P42858 2/20 0.54
GFER P55789 1/20 0.54
LMNA P02545 2/20 0.50
MYC P01106 1/20 0.49
NR4A1 P22736 1/20 0.49
CTSB P07858 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
L3MBTL1 Q9Y468 3/20 0.45
USP2 O75604 1/20 0.45
HSD17B10 Q99714 1/20 0.45
TP53 P04637 1/20 0.43
GAA P10253 1/20 0.43
KMT2A Q03164 2/20 0.42
MAPT P10636 2/20 0.42
BCL2A1 Q16548 1/20 0.42
MEN1 O00255 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7031169 0.84 MYC (0.59) POLBNOTUMALDH1A1HTTGFER
SCHEMBL31576799 0.77 TP53 (0.49) NOTUMALDH1A1HTTGFERLMNA
SCHEMBL9624259 0.77 TP53 (0.49) NOTUMALDH1A1HTTGFERLMNA
SCHEMBL11462311 0.73 NOTUM (0.59) POLBNOTUMALDH1A1HTTGFER
SCHEMBL11608487 0.72 TP53 (0.53) NOTUMALDH1A1HTTGFERUSP2
SCHEMBL11881996 0.72 NOTUM (0.44) NOTUMALDH1A1HTTGFERLMNA
SCHEMBL9370346 0.71 POLB (0.64) POLBNOTUMALDH1A1LMNAMYC
SCHEMBL15871992 0.71 TDP1 (0.59) POLBNOTUMALDH1A1HTTGFER
Hydrochloric Acid SCHEMBL5468118 0.71 POLB (0.63) POLBNOTUMALDH1A1HTTMYC
SCHEMBL11455608 0.71 BCL2A1 (0.60) ALDH1A1LMNAKMT2AMAPTBCL2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-56065871-A None JP disclosed
JP-S5665871-A 1- SUBSTITUTED PHENYL -2,6-DIMETHYL-4-PYRIDONE, ITS PREPARATION AND PESTICIDE TOKYO ORGAN CHEM IND LTD 1981-06-03 JP disclosed