Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H3 | Q13133 | 4/20 | 0.74 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.74 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.52 |
| ▸ | TDP2 | O95551 | 1/20 | 0.52 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11306835 | 1.00 | NR1H3 (0.74) | NR1H3NR1H2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11590519 | 0.90 | NR1H3 (0.69) | NR1H3NR1H2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11555265 | 0.85 | NR1H3 (1.00) | NR1H3NR1H2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11590621 | 0.83 | NR1H3 (0.83) | NR1H3NR1H2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11311344 | 0.82 | NR1H3 (0.71) | NR1H3NR1H2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11592344 | 0.79 | NPC1 (0.54) | NR1H3NR1H2RAB9ANPC1MEN1 | |
| SCHEMBL11589348 | 0.78 | NR1H3 (0.54) | NR1H3NR1H2RAB9ANPC1LMNA | |
| SCHEMBL6975297 | 0.78 | NR1H3 (0.61) | NR1H3NR1H2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11592259 | 0.76 | NR1H2 (0.60) | NR1H3NR1H2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11589058 | 0.76 | NR1H2 (0.60) | NR1H3NR1H2RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4256887-A | ANTIGOUT, HYPOURICOMIA | MERCK & CO., INC. (US) | 1981-03-17 | — | — | US | disclosed |
| US-4198513-A | ANTI-GOUT AND ANTI-HYPERURICEMIC AGENTS | MERCK & CO., INC. (US) | 1980-04-15 | — | — | US | disclosed |
| US-4156085-A | ANTIGOUT, XANTHINE OXIDASE INHIBITORS | MERCK & CO., INC. (US) | 1979-05-22 | — | — | US | disclosed |
| US-4102889-A | ANTIGOUT AND ANTIHYPERURICEMIC AGENTS | MERCK & CO., INC. (US) | 1978-07-25 | — | — | US | disclosed |
| US-4071518-A | Di-and tri-substituted 1,2,4-triazoles | MERCK & CO., INC. (US) | 1978-01-31 | — | — | US | disclosed |
| US-4011218-A | ANTI-GOUT, ANTI-HYPERURICEMIC | MERCK & CO., INC. (US) | 1977-03-08 | — | — | US | disclosed |