Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.61 |
| ▸ | ACE | P12821 | 9/20 | 0.60 |
| ▸ | CMA1 | P23946 | 9/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11313575 | 1.00 | KLK5 (0.61) | KLK5ACECMA1LMNAACE2 | |
| SCHEMBL11314535 | 0.89 | PREP (0.58) | KLK5ACELMNAACE2 | |
| SCHEMBL11314532 | 0.89 | PREP (0.58) | KLK5ACELMNAACE2 | |
| SCHEMBL7354560 | 0.84 | KLK5 (0.59) | KLK5ACECMA1 | |
| SCHEMBL7354569 | 0.84 | KLK5 (0.59) | KLK5ACECMA1 | |
| SCHEMBL3692081 | 0.83 | ACE (0.77) | KLK5ACECMA1ACE2 | |
| SCHEMBL3692085 | 0.83 | ACE (0.77) | KLK5ACECMA1ACE2 | |
| SCHEMBL22409423 | 0.83 | ACE (0.77) | KLK5ACECMA1ACE2 | |
| SCHEMBL5900836 | 0.83 | ACE (0.77) | KLK5ACECMA1ACE2 | |
| SCHEMBL5900839 | 0.83 | ACE (0.77) | KLK5ACECMA1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4293481-A | AND USEFUL AS HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1981-10-06 | — | — | US | disclosed |