Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.58 |
| ▸ | ACE | P12821 | 10/20 | 0.57 |
| ▸ | REN | P00797 | 1/20 | 0.52 |
| ▸ | ACE2 | Q9BYF1 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | CTSD | P07339 | 1/20 | 0.49 |
| ▸ | CTSE | P14091 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | ELANE | P08246 | 1/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11314535 | 1.00 | PREP (0.58) | PREPACERENACE2LMNA | |
| SCHEMBL11313575 | 0.89 | KLK5 (0.61) | ACEACE2LMNAKLK5 | |
| SCHEMBL11313573 | 0.89 | KLK5 (0.61) | ACEACE2LMNAKLK5 | |
| SCHEMBL8611219 | 0.88 | PREP (0.67) | PREPACERENACE2LMNA | |
| SCHEMBL8611215 | 0.88 | PREP (0.67) | PREPACERENACE2LMNA | |
| SCHEMBL7871516 | 0.88 | PREP (0.72) | PREPACEACE2LMNAELANE | |
| SCHEMBL7334484 | 0.88 | PREP (0.72) | PREPACEACE2LMNAELANE | |
| SCHEMBL22209468 | 0.88 | PREP (0.72) | PREPACEACE2LMNAELANE | |
| SCHEMBL10657907 | 0.84 | PREP (0.67) | PREPACEACE2LMNAELANE | |
| SCHEMBL9438697 | 0.84 | PREP (0.67) | PREPACEACE2LMNAELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4293481-A | AND USEFUL AS HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1981-10-06 | — | — | US | claimed |
| US-4293481-A | AND USEFUL AS HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1981-10-06 | — | — | US | disclosed |