⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15063579 | 0.80 | — | — | |
| SCHEMBL3518 | 0.71 | — | — | |
| SCHEMBL232809 | 0.71 | — | — | |
| SCHEMBL15063863 | 0.69 | METAP2 (0.36) | — | |
| SCHEMBL28082266 | 0.69 | — | — | |
| SCHEMBL27645637 | 0.69 | — | — | |
| SCHEMBL15353345 | 0.67 | NOTUM (0.30) | — | |
| SCHEMBL3336875 | 0.67 | ESR1 (0.33) | — | |
| SCHEMBL193857 | 0.67 | — | — | |
| SCHEMBL146776 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242945-B2 | Substituted 2-benzylidene-2H-benzo[b][1,4]thiazin-3(4H)-ones, derivatives thereof, and therapeutic uses thereof | Temple University—Of the Commonwealth System of Higher Education (US) | 2016-01-26 | — | — | US | claimed |
| US-20140086941-A1 | SUBSTITUTED 2-BENZYLIDENE-2H-BENZO[b][1,4]THIAZIN-3(4H)-ONES, DERIVATIVES THEREOF, AND THERAPEUTIC USES THEREOF | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2014-03-27 | — | — | US | claimed |
| WO-2012166586-A1 | SUBSTITUTED 2-BENZYLIDENE-2H-BENZO[b][1,4]THIAZIN-3(4H)-ONES, DERIVATIVES THEREOF, AND THERAPEUTIC USES THEREOF | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-12-06 | — | — | WO | claimed |
| EP-1379498-B1 | SULPHONES WHICH MODULATE THE ACTION OF GAMMA SECRETASE | MERCK SHARP & DOHME (GB) | 2011-02-16 | — | — | EP | claimed |
| US-7595344-B2 | Sulphones which modulate the action of gamma secretase | MERCK SHARP & DOHME LIMITED (GB) | 2009-09-29 | — | — | US | claimed |
| US-20090131419-A1 | Sulphones which modulate the action of gamma secretase | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2009-05-21 | — | — | US | claimed |
| US-20070213329-A1 | Sulphones which modulate the action of gammasecretase | MERCK SHARP & DOHME (UK) LIMITED (GB) | 2007-09-13 | — | — | US | claimed |
| US-20060183780-A1 | Pyrazole compounds useful in the treatment of inflammation | BIOLIPOX AB (SE) | 2006-08-17 | — | — | US | claimed |
| EP-1603897-A1 | PYRAZOLE COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2005-12-14 | — | — | EP | claimed |
| WO-2004080999-A1 | PYRAZOLE COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2004-09-23 | — | — | WO | claimed |
| US-20040116404-A1 | Sulphones which modulate the action of gamma secretase | MERCK SHARP & DOHME LTD. (GB) | 2004-06-17 | — | — | US | claimed |
| EP-1379498-A1 | SULPHONES WHICH MODULATE THE ACTION OF GAMMA SECRETASE | MERCK SHARP & DOHME LTD. (GB) | 2004-01-14 | — | — | EP | claimed |
| WO-2002081435-A1 | SULPHONES WHICH MODULATE THE ACTION OF GAMMA SECRETASE | MERCK SHARP & DOHME LIMITED (GB) | 2002-10-17 | — | — | WO | claimed |
| CN-116444481-A | 4-arylthiophene carboxylic acid compounds as ANO1 protein inhibitors | 北京大学 | 2023-07-18 | — | — | CN | disclosed |
| CN-107406440-B | BACE1 inhibitors | 豪夫迈·罗氏有限公司 | 2021-05-07 | — | — | CN | disclosed |
| EP-2927218-B1 | TETRAZOLINONE COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL CO (JP) | 2018-07-04 | — | — | EP | disclosed |
| US-20040116404-A1 | Sulphones which modulate the action of gamma secretase | MERCK SHARP & DOHME LTD. (GB) | 2004-06-17 | — | — | US | disclosed |
| WO-2004013090-A1 | SYNTHESIS OF CYCLOHEXANONE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 2004-02-12 | — | — | WO | disclosed |
| EP-1379498-A1 | SULPHONES WHICH MODULATE THE ACTION OF GAMMA SECRETASE | MERCK SHARP & DOHME LTD. (GB) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002081435-A1 | SULPHONES WHICH MODULATE THE ACTION OF GAMMA SECRETASE | MERCK SHARP & DOHME LIMITED (GB) | 2002-10-17 | — | — | WO | disclosed |