Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11319132 | 0.80 | PDE3B (0.73) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL649984 | 0.76 | GPR119 (0.56) | PDE3BPDE3AGPR119PDE2A | |
| SCHEMBL11326849 | 0.74 | PDE3B (0.70) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11283614 | 0.72 | MAPT (0.68) | PDE3BPDE3AGPR119PDE2A | |
| SCHEMBL11325987 | 0.70 | PDE3B (0.69) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL7414941 | 0.67 | PDE3B (0.48) | PDE3BPDE3AGPR119PDE2APDE4A | |
| SCHEMBL10902870 | 0.66 | PDE3B (1.00) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL9639134 | 0.66 | GPR119 (0.48) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL9781549 | 0.65 | GPR119 (0.55) | PDE3BPDE3AGPR119PDE2A | |
| SCHEMBL10520569 | 0.65 | GPR119 (0.60) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4258185-A | HYPOTENSIVE, ANTITHROMBOTIC AGENTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1981-03-24 | — | — | US | disclosed |