Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.30 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11100271 | 0.81 | HRH1 (0.49) | NPC1RAB9ACYP2A6CXCR4HRH1 | |
| SCHEMBL436325 | 0.81 | NPC1 (0.34) | NPC1RAB9AL3MBTL1ALDH1A1LMNA | |
| SCHEMBL4625922 | 0.81 | TDP1 (0.49) | NPC1RAB9AL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL28667999 | 0.80 | TDP1 (0.47) | NPC1RAB9AL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL29467768 | 0.80 | TDP1 (0.47) | NPC1RAB9AL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL28680286 | 0.80 | TDP1 (0.47) | NPC1RAB9AL3MBTL1LMNASMN1; SMN2 | |
| Bromide SCHEMBL11605798 | 0.80 | HRH1 (0.47) | NPC1RAB9ACYP2A6CXCR4HRH1 | |
| SCHEMBL9143648 | 0.80 | TDP1 (0.47) | NPC1RAB9AL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL1469935 | 0.80 | TDP1 (0.47) | NPC1RAB9AL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL28676139 | 0.80 | TDP1 (0.47) | NPC1RAB9AL3MBTL1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4255428-A | ANTIINFLAMMATORY AGENTS, HISTAMINE BLOCKING AGENTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-03-10 | — | — | US | disclosed |