Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9143648 | 0.98 | TDP1 (0.47) | TDP1L3MBTL1KCNH2PPARAGRM2 | |
| SCHEMBL28130836 | 0.98 | TDP1 (0.47) | TDP1L3MBTL1KCNH2PPARAGRM2 | |
| SCHEMBL28676139 | 0.98 | TDP1 (0.47) | TDP1L3MBTL1KCNH2PPARAGRM2 | |
| SCHEMBL29467768 | 0.98 | TDP1 (0.47) | TDP1L3MBTL1KCNH2PPARAGRM2 | |
| SCHEMBL28667999 | 0.98 | TDP1 (0.47) | TDP1L3MBTL1KCNH2PPARAGRM2 | |
| SCHEMBL1469935 | 0.98 | TDP1 (0.47) | TDP1L3MBTL1KCNH2PPARAGRM2 | |
| SCHEMBL28680286 | 0.98 | TDP1 (0.47) | TDP1L3MBTL1KCNH2PPARAGRM2 | |
| SCHEMBL10268371 | 0.94 | L3MBTL1 (0.42) | TDP1L3MBTL1PPARAGRM2CYP3A4 | |
| SCHEMBL3066461 | 0.86 | PDE3B (0.38) | L3MBTL1GRM2NPC1RAB9AKDM4E | |
| SCHEMBL11100271 | 0.81 | HRH1 (0.49) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102344410-A | Arylpyridine ortho-position monohalogenated compounds and synthesis method thereof | UNIV SHANGHAI | 2012-02-08 | — | — | CN | disclosed |
| EP-1948605-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007061741-A2 | MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |