Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 3/20 | 0.37 |
| ▸ | MERTK | Q12866 | 12/20 | 0.35 |
| ▸ | AXL | P30530 | 3/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 3/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10322947 | 0.92 | CCNT1 (0.35) | CCNT1MERTKFLT3 | |
| SCHEMBL10323252 | 0.81 | MERTK (0.36) | MERTKAXLTYRO3CCNE2CCNA2 | |
| SCHEMBL10322157 | 0.80 | MERTK (0.43) | CCNT1MERTKAXLTYRO3FLT3 | |
| SCHEMBL10323155 | 0.76 | MERTK (0.37) | MERTKAXLTYRO3 | |
| SCHEMBL10322433 | 0.75 | MERTK (0.36) | MERTKAXLTYRO3FLT3 | |
| SCHEMBL10322642 | 0.73 | MERTK (0.41) | MERTKAXLTYRO3CCNE2CCNA2 | |
| SCHEMBL10324425 | 0.73 | MERTK (0.50) | MERTKAXLTYRO3 | |
| SCHEMBL10324360 | 0.72 | MERTK (0.41) | CCNT1MERTKAXLTYRO3FLT3 | |
| SCHEMBL10323426 | 0.71 | MERTK (0.37) | MERTKAXLTYRO3FLT3 | |
| SCHEMBL10322741 | 0.71 | MERTK (0.49) | CCNT1MERTKAXLTYRO3FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098068-A1 | PYRAZOLO PYRIMIDINES AS DYRK1A AND DYRK1B INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |