SCHEMBL11322151

SCHEMBL11322151

COC(c1ccccc1)c1ccccc1Br

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 7/20 0.65
TDO2 P48775 7/20 0.65
CYP2C19 P33261 3/20 0.40
CYP3A4 P08684 2/20 0.40
ALDH1A1 P00352 1/20 0.40
ALOX15 P16050 1/20 0.40
IDO2 Q6ZQW0 2/20 0.39
CYP2C9 P11712 2/20 0.38
OPRM1 P35372 4/20 0.37
CHRM2 P08172 3/20 0.37
ADRA2A P08913 3/20 0.37
CHRM1 P11229 3/20 0.37
SLC6A2 P23975 3/20 0.37
SLC6A4 P31645 3/20 0.37
DRD3 P35462 3/20 0.37
SLC6A3 Q01959 3/20 0.37
DRD1 P21728 2/20 0.37
HTR1A P08908 1/20 0.37
TBXA2R P21731 1/20 0.37
NPSR1 Q6W5P4 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11862661 0.87 IDO1 (0.50) IDO1TDO2CYP2C19CYP3A4ALDH1A1
SCHEMBL31395293 0.85 IDO1 (0.49) IDO1TDO2CYP2C19CYP3A4ALDH1A1
SCHEMBL1928305 0.83 IDO1 (0.69) IDO1TDO2CYP2C19CYP3A4IDO2
SCHEMBL461448 0.78 IDO1 (0.47) IDO1TDO2OPRM1CHRM2ADRA2A
SCHEMBL14361130 0.78 ESR1 (0.59) IDO1TDO2CYP2C19CYP3A4IDO2
SCHEMBL1952981 0.76 GABRA1 (0.48) IDO1TDO2CYP2C19IDO2OPRM1
SCHEMBL23296602 0.75 IDO1 (0.46) IDO1TDO2OPRM1CHRM2ADRA2A
SCHEMBL1773224 0.75 SLC6A4 (0.54) IDO1TDO2ALDH1A1OPRM1CHRM2
SCHEMBL6325 0.74 CYP2C19 (0.44) IDO1TDO2CYP2C19CYP3A4ALDH1A1
SCHEMBL29369499 0.74 CYP2C19 (0.44) IDO1TDO2CYP2C19CYP3A4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4301292-A 1-[2-(4,5-Dihydro-4,4-dialkyl-2-oxazolyl)phenyl]-4-(dialkylamino)cyclohexanol HOECHST-ROUSSEL PHARMACEUTICALS, INCORPORATED (US) 1981-11-17 US disclosed
US-4292243-A 3\"-Phenyldispiro[1,3-dioxolane-2,4'-cyclohexane-1',1\"-(3\"H)-isobenzofuran] HOECHST ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1981-09-29 US disclosed
US-4292245-A 3'-Phenylspiro[cyclohexane-1,1'(3'H)-isobenzofuran]-4-one HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1981-09-29 US disclosed
US-4290958-A Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1981-09-22 US disclosed
US-4288623-A 1-Aryl-4-amino-cyclohexan-1-ols HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1981-09-08 US disclosed
EP-0027522-A1 Spiro(cyclohexane-1,1'(3'H)-isobenzofuran)s, processes and intermediates for their preparation and pharmaceutical compositions containing them HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1981-04-29 EP disclosed
US-3959475-A ANTIDEPRESSANT, TRANQUILIZER, ANALGESIC AMERICAN HOECHST CORPORATION (US) 1976-05-25 US disclosed
US-3957828-A 3-Aminoalkyl-1,3-dihydro-3-phenylspiro[isobenzofurans] AMERICAN HOECHST CORPORATION (US) 1976-05-18 US disclosed