Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 17/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 17/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | PDE5A | O76074 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | PTAFR | P25105 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
| ▸ | PDE1A | P54750 | 1/20 | 0.71 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.71 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.71 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | P2RY12 | Q9H244 | 11/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11312303 | 0.90 | PDE3B (0.71) | PDE3BPDE3AMEN1KMT2AKDM4E | |
| SCHEMBL11310353 | 0.88 | PDE3B (0.55) | PDE3BPDE3AMEN1KMT2AKDM4E | |
| SCHEMBL11324766 | 0.86 | PDE3B (0.79) | PDE3BPDE3AMEN1KMT2AKDM4E | |
| SCHEMBL11308944 | 0.84 | PDE3B (0.51) | PDE3BPDE3AMEN1KMT2AKDM4E | |
| Cilostamide SCHEMBL29491047 | 0.83 | PDE3B (1.00) | PDE3BPDE3AMEN1KMT2AKDM4E | |
| Cilostamide SCHEMBL49742 | 0.83 | PDE3B (1.00) | PDE3BPDE3AMEN1KMT2AKDM4E | |
| SCHEMBL11317158 | 0.83 | PDE3B (1.00) | PDE3BPDE3AMEN1KMT2AKDM4E | |
| SCHEMBL11313093 | 0.82 | PDE3B (0.92) | PDE3BPDE3AMEN1KMT2AKDM4E | |
| SCHEMBL29855225 | 0.82 | PDE3B (0.72) | PDE3BPDE3AMEN1KMT2AKDM4E | |
| Cilostamide SCHEMBL11310308 | 0.81 | PDE3B (0.94) | PDE3BPDE3AMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4298739-A | ANTICOAGULANTS, ANTIINFLAMMATORY, ANTIULCER, VASODILATOR, PHOSPHODIESTERASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1981-11-03 | — | — | US | claimed |
| US-4298739-A | ANTICOAGULANTS, ANTIINFLAMMATORY, ANTIULCER, VASODILATOR, PHOSPHODIESTERASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1981-11-03 | — | — | US | disclosed |