Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11402954 | 0.75 | QDPR (0.41) | — | |
| SCHEMBL8967404 | 0.75 | SLC18A3 (0.49) | SLC18A3SIGMAR1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL26773893 | 0.75 | PTPN2 (0.35) | NPC1RAB9AKMT2APRMT5WDR77 | |
| SCHEMBL26773896 | 0.75 | PTPN2 (0.35) | NPC1RAB9AKMT2APRMT5WDR77 | |
| SCHEMBL18527253 | 0.74 | — | — | |
| SCHEMBL19514190 | 0.73 | NPC1 (0.42) | NPC1RAB9AKMT2APRMT5WDR77 | |
| SCHEMBL28151532 | 0.71 | NPC1 (0.45) | NPC1RAB9AKMT2APRMT5WDR77 | |
| SCHEMBL10975587 | 0.64 | — | — | |
| SCHEMBL3944983 | 0.62 | — | — | |
| SCHEMBL3944984 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0038003-A2 | Antidepressant pyrrolylpiperidines | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-10-21 | — | — | EP | claimed |
| US-4267185-A | SAID PYRROLYLPIPERIDINES BEING 1,2,3,6-TETRAHYDRO-1-METHYL-4-(1-METHYLPYRROL-2-YL)PYRIDINE OR 1-METHYL-4-(1-METHYLPYRROL-2-YL)-4-PIPERIDINOL | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-05-12 | — | — | US | claimed |