Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.61 |
| ▸ | CYP11B1 | P15538 | 14/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 13/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11316667 | 0.89 | PDE3B (0.65) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL11328012 | 0.83 | PDE3B (0.72) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL11333317 | 0.80 | PDE3B (0.50) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL9718419 | 0.76 | PDE3B (1.00) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL11326023 | 0.73 | PDE3B (0.48) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11323274 | 0.73 | PDE3B (0.55) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL11324287 | 0.73 | PDE3B (0.57) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL11329147 | 0.69 | PDE3B (0.80) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10810733 | 0.69 | PDE3B (0.69) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL11090751 | 0.68 | PDE3B (0.65) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4258185-A | HYPOTENSIVE, ANTITHROMBOTIC AGENTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1981-03-24 | — | — | US | disclosed |