Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 7/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11316667 | 0.89 | PDE3B (0.65) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL11323274 | 0.86 | PDE3B (0.55) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL11324287 | 0.86 | PDE3B (0.57) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL11315739 | 0.81 | PDE3B (0.74) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL11324327 | 0.80 | PDE3B (0.61) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL11326023 | 0.77 | PDE3B (0.48) | PDE3BPDE3AGPR119 | |
| SCHEMBL10704316 | 0.75 | PDE3B (0.50) | PDE3BPDE3AGPR119 | |
| SCHEMBL11328012 | 0.74 | PDE3B (0.72) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL11086404 | 0.73 | CYP1A2 (0.52) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 | |
| SCHEMBL11087392 | 0.71 | CYP1A2 (0.50) | PDE3BPDE3ACYP1A2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4258185-A | HYPOTENSIVE, ANTITHROMBOTIC AGENTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1981-03-24 | — | — | US | claimed |
| US-4258185-A | HYPOTENSIVE, ANTITHROMBOTIC AGENTS | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1981-03-24 | — | — | US | disclosed |