Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Cystamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.59 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.59 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.59 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.59 |
| ▸ | THPO | P40225 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cystamine SCHEMBL8660518 | 1.00 | TSHR (0.59) | TSHRGLRA1SLC6A9OR51E2THPO | |
| Cystamine SCHEMBL9417963 | 0.88 | TSHR (0.67) | TSHRGLRA1SLC6A9OR51E2THPO | |
| Cystamine SCHEMBL28779847 | 0.86 | TSHR (0.63) | TSHRGLRA1SLC6A9OR51E2THPO | |
| SCHEMBL142602 | 0.86 | TSHR (0.72) | TSHRGLRA1SLC6A9OR51E2THPO | |
| Cystamine SCHEMBL31646100 | 0.85 | TSHR (0.62) | TSHRGLRA1SLC6A9OR51E2THPO | |
| Cystamine SCHEMBL445194 | 0.85 | TSHR (0.62) | TSHRGLRA1SLC6A9OR51E2THPO | |
| Hydrochloric Acid SCHEMBL1728032 | 0.83 | TSHR (0.68) | TSHRGLRA1SLC6A9OR51E2THPO | |
| SCHEMBL12798150 | 0.83 | — | — | |
| Cystamine SCHEMBL9187225 | 0.83 | TSHR (0.46) | TSHRGLRA1SLC6A9OR51E2THPO | |
| Cystamine SCHEMBL9187228 | 0.82 | TSHR (0.59) | TSHRGLRA1SLC6A9OR51E2THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212466-A1 | Thiol-Modified Surface Immobilization Article And Method | CORNING INCORPORATED | 2011-09-01 | — | — | US | disclosed |
| EP-2287610-A1 | Thiol-modified surface immobilization article and method | Corning Incorporated (US) | 2011-02-23 | — | — | EP | disclosed |