Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.76 |
| ▸ | DRD4 | P21917 | 2/20 | 0.76 |
| ▸ | DRD3 | P35462 | 2/20 | 0.76 |
| ▸ | HTR2A | P28223 | 1/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6991477 | 0.91 | DRD2 (0.71) | DRD2DRD4DRD3HTR2AADRA1D | |
| SCHEMBL11619083 | 0.90 | DRD2 (0.62) | DRD2DRD4DRD3HTR2AADRA2A | |
| SCHEMBL11786949 | 0.90 | DRD2 (0.62) | DRD2DRD4DRD3HTR2AADRA2A | |
| Hydrochloric Acid SCHEMBL11222340 | 0.90 | DRD2 (0.70) | DRD2DRD4DRD3HTR2AADRA1D | |
| SCHEMBL11785874 | 0.86 | KCNH2 (0.61) | DRD2DRD4DRD3HTR2AHTR1A | |
| SCHEMBL24746503 | 0.85 | HTR2A (0.74) | DRD2DRD4DRD3HTR2AADRA2A | |
| SCHEMBL6465788 | 0.84 | HTR2A (0.88) | DRD2DRD4DRD3HTR2AADRA2A | |
| SCHEMBL10413887 | 0.84 | DRD2 (0.68) | DRD2DRD4DRD3HTR2AADRA1D | |
| SCHEMBL5339006 | 0.84 | DRD2 (0.75) | DRD2DRD4DRD3HTR2AADRA2A | |
| SCHEMBL7954617 | 0.84 | HTR2A (0.72) | DRD2DRD4DRD3HTR2AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE28973-E | PARKINSON'S DISEASE | A. H. ROBINS COMPANY, INCORPORATED (US) | 1976-09-21 | — | — | US | claimed |
| US-4302589-A | ANTIPSYCHOTIC | AMERICAN CYANAMID COMPANY (US) | 1981-11-24 | — | — | US | disclosed |
| US-RE28973-E | PARKINSON'S DISEASE | A. H. ROBINS COMPANY, INCORPORATED (US) | 1976-09-21 | — | — | US | disclosed |