Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.60 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10318061 | 0.84 | DYRK1A (0.85) | DYRK1ADYRK1BALDH1A1HPGDKDM4E | |
| SCHEMBL10317577 | 0.84 | DYRK1A (0.85) | DYRK1ADYRK1BALDH1A1HPGDKDM4E | |
| SCHEMBL10318579 | 0.84 | DYRK1A (0.69) | DYRK1ADYRK1BALDH1A1 | |
| SCHEMBL10319867 | 0.83 | DYRK1A (0.54) | DYRK1ADYRK1BALDH1A1HPGDKDM4E | |
| SCHEMBL10318671 | 0.83 | DYRK1A (0.54) | DYRK1ADYRK1BALDH1A1HPGDKDM4E | |
| SCHEMBL10321365 | 0.81 | DYRK1A (0.80) | DYRK1ADYRK1BALDH1A1HPGDKDM4E | |
| SCHEMBL10320719 | 0.80 | DYRK1A (0.52) | DYRK1ADYRK1BALDH1A1HPGDKDM4E | |
| SCHEMBL10320590 | 0.80 | DYRK1A (0.49) | DYRK1ADYRK1BALDH1A1HPGDKDM4E | |
| SCHEMBL11407554 | 0.79 | SRD5A1 (0.45) | DYRK1ADYRK1BALDH1A1HPGDKDM4E | |
| SCHEMBL10321615 | 0.79 | RAB9A (0.50) | DYRK1ADYRK1BALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012098070-A1 | QUINOLINE DYRK1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-07-26 | — | — | WO | disclosed |