Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | POLB | P06746 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12669736 | 0.78 | MAPT (0.52) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL1133645 | 0.76 | MAPT (0.50) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL1133647 | 0.76 | MAPT (0.50) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL1865392 | 0.73 | MAPT (0.47) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL1865394 | 0.73 | MAPT (0.47) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL4221175 | 0.73 | MAPT (0.60) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL8798630 | 0.73 | MAPT (0.60) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL30052762 | 0.73 | MAPT (0.60) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL4221172 | 0.73 | MAPT (0.60) | MAPTALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL8798626 | 0.73 | MAPT (0.60) | MAPTALDH1A1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2285801-A1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | Nerviano Medical Sciences S.r.l. (IT) | 2011-02-23 | — | — | EP | disclosed |
| WO-2009133170-A1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-11-05 | — | — | WO | disclosed |