Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 7/20 | 0.40 |
| ▸ | CNR2 | P34972 | 6/20 | 0.40 |
| ▸ | AHR | P35869 | 2/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | F3 | P13726 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30679520 | 1.00 | KDM4E (0.43) | KDM4EMAPTTDP1CHEK1CNR1 | |
| SCHEMBL13731265 | 0.86 | CHEK1 (0.41) | KDM4EMAPTTDP1CHEK1AHR | |
| SCHEMBL13731006 | 0.80 | JAK2 (0.41) | KDM4ECHEK1AHRF7LTA4H | |
| SCHEMBL13732354 | 0.80 | CHEK1 (0.40) | KDM4ECHEK1AHRF7LTA4H | |
| SCHEMBL9316783 | 0.79 | LRRK2 (0.47) | KDM4ETDP1TP53MEN1LMNA | |
| SCHEMBL13730708 | 0.76 | CHEK1 (0.40) | KDM4EMAPTTDP1CHEK1MCL1 | |
| SCHEMBL27260826 | 0.75 | KDM4E (0.48) | KDM4EMAPTTDP1CNR1CNR2 | |
| SCHEMBL7784781 | 0.74 | MCL1 (0.49) | KDM4ETDP1CHEK1AHRF7 | |
| SCHEMBL9221741 | 0.74 | KMO (0.45) | KDM4EMAPTAHRMEN1LMNA | |
| SCHEMBL1404496 | 0.73 | CNR1 (0.49) | KDM4ECNR1CNR2LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240217969-A1 | SUBSTITUTED PYRROLE CARBOXAMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2024-07-04 | — | — | US | disclosed |
| EP-4313971-A1 | SUBSTITUTED PYRROLE CARBOXAMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2024-02-07 | — | — | EP | disclosed |
| CN-117157289-A | Substituted pyrrolecarboxamides, process for their preparation and their use as kinase inhibitors | 内尔维亚诺医疗科学公司 | 2023-12-01 | — | — | CN | disclosed |
| WO-2022207404-A1 | SUBSTITUTED PYRROLE CARBOXAMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2022-10-06 | — | — | WO | disclosed |
| EP-2285801-B1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-10-09 | — | — | EP | disclosed |
| EP-2285801-B1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-10-09 | — | — | EP | disclosed |
| US-8399668-B2 | Process for the preparation of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carboxamides | NERVIANO MEDICAL SCIENCES S. R. L. (IT) | 2013-03-19 | — | — | US | disclosed |
| US-8399668-B2 | Process for the preparation of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carboxamides | NERVIANO MEDICAL SCIENCES S. R. L. (IT) | 2013-03-19 | — | — | US | disclosed |
| US-8399668-B2 | Process for the preparation of 5-(2-amino-pyrimidin-4-yl)-2-aryl-1H-pyrrole-3-carboxamides | NERVIANO MEDICAL SCIENCES S. R. L. (IT) | 2013-03-19 | — | — | US | disclosed |
| EP-2285801-A1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | Nerviano Medical Sciences S.r.l. (IT) | 2011-02-23 | — | — | EP | disclosed |
| US-20110040090-A1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-02-17 | — | — | US | disclosed |
| US-20110040090-A1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-02-17 | — | — | US | disclosed |
| US-20110040090-A1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2011-02-17 | — | — | US | disclosed |
| WO-2009133170-A1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-11-05 | — | — | WO | disclosed |
| WO-2009133170-A1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2009-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110040090-A1 | PROCESS FOR THE PREPARATION OF 5-(2-AMINO-PYRIMIDIN-4-YL)-2-ARYL-1H-PYRROLE-3-CARBOXAMIDES | CDC7, CDK7, CDK17 | KDM4E 342/4885MAPT 3460/4885TDP1 1761/4885 |
| US-20240217969-A1 | SUBSTITUTED PYRROLE CARBOXAMIDES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS | CDC7, CDK7, CDK17 | KDM4E 667/4885MAPT 2344/4885TDP1 1088/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.