KMO — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL287227	0.58	19/20
SCHEMBL163539	0.50	19/20
SCHEMBL163540	0.50	19/20
SCHEMBL232129	0.52	18/20
SCHEMBL71141	0.59	16/20
SCHEMBL87765	0.50	14/20
SCHEMBL18030	0.67	7/20
SCHEMBL18031	0.67	7/20
SCHEMBL18032	0.67	7/20
SCHEMBL202448	0.59	7/20
SCHEMBL231979	0.50	7/20
SCHEMBL18342	0.65	5/20
SCHEMBL18343	0.65	5/20
SCHEMBL109465	0.50	5/20
SCHEMBL127480	0.50	5/20
SCHEMBL78430	0.40	5/20
SCHEMBL121809	0.68	4/20
SCHEMBL121813	0.68	4/20
SCHEMBL18344	0.67	4/20
SCHEMBL91363	0.58	4/20

Clinical trials — most relevant to KMO by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effects of Melatonin on Elevated Liver Enzymes During Statins Treatment	PHASE4	COMPLETED
Ketamine's Efficiency in the Treatment of Chronic Pain: Kynurenin Pathway	PHASE3	UNKNOWN
Safety and Antiemetic Efficacy of Akynzeo Plus Dexamethasone During Radiotherapy and Concomitant Weekly Cisplatin	PHASE2/PHASE3	UNKNOWN
Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders	PHASE2	COMPLETED
Folate Rechallenge	PHASE2	COMPLETED
Study to Explore the Safety, Tolerability and Efficacy of MK-3475 in Combination With INCB024360 in Participants With Selected Cancers	PHASE1/PHASE2	COMPLETED
A Study of the Effects of a New Antidepressant Treatment (GSK561679) in Females With Major Depressive Disorder	PHASE2	COMPLETED
Biomarker Study of PDR001 in Combination With MCS110 in Gastric Cancer	PHASE2	UNKNOWN
A Phase 2 Efficacy and Safety Study of TAK-063 in Participants With an Acute Exacerbation of Schizophrenia	PHASE2	COMPLETED
Diclofenac Dose Response Study	PHASE1	RECRUITING
TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke	nan	COMPLETED
An Assessment of Cognitive Function in Irritable Bowel Syndrome	nan	UNKNOWN
Tryptophan Metabolism in Healthy Young Adults	nan	COMPLETED
Biological Triggers of Depression in Pregnancy	nan	COMPLETED
A Longitudinal Study of Inflammatory Pathways in Depression	nan	COMPLETED
Mechanisms to Reduce Mental and Physical Fatigue Following Exercise Training in Older Adults	nan	COMPLETED
Blood Levels of Ketamine in Patients Using Topical Application of 10% Ketamine Gel for Neuropathic Pain	nan	UNKNOWN
Assesment of Vitamin B6 Level in Patients With Major Depressive Disorder	nan	UNKNOWN
Disturbances of Kynurenine Pathway of Trytophan Metabolism in Schizophrenia: A Quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR) Study	nan	COMPLETED
Nutritional Impacts of Palynziq on Patients With Phenylketonuria (PKU)	nan	RECRUITING
Nutritional and Neurotransmitter Changes in PKU Subjects on BH4	nan	COMPLETED
In Vivo Assessment of Histamine Pharmacodynamics	nan	WITHDRAWN
Evaluation of the Relationship Between Bruxism and Tryptophan Metabolites	nan	COMPLETED
Role of Inflammation in Psychiatric Disorders in Patients With Cutaneous Lupus	nan	COMPLETED
Resistance Training to Improve Fatigue and Physical Function in Postmenopausal Breast Cancer Survivors	nan	COMPLETED
Vancomycin Associated Red Man Syndrome (RMS)	nan	COMPLETED
Blood Biomarkers in Electroconvulsive Therapy	nan	ENROLLING_BY_INVITATION
Pharmacogenomics of Antidepressant Response in Children and Adolescents	nan	COMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
The Role of Dietary Tryptophan on Aryl Hydrocarbon Receptor Activation	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a KMO binder may also engage these)

Protein	Name	Similarity
Q9MZS9	—	1.000	Q9MZS9 →
Q91WN4	—	0.999	Q91WN4 →
Q6DIZ8	—	0.998	Q6DIZ8 →
O88867	—	0.995	O88867 →
Q1RLY6	—	0.992	Q1RLY6 →
F1RAX8	—	0.966	F1RAX8 →
Q6DF46	—	0.966	Q6DF46 →
P52019	—	0.962	P52019 →
E9Q4Z2	—	0.961	E9Q4Z2 →
F4JJJ3	—	0.960	F4JJJ3 →
SQLE	Squalene monooxygenase	0.959	landscape →
B4G0F3	—	0.959	B4G0F3 →
Q2KIL4	—	0.956	Q2KIL4 →
Q2GQG8	—	0.956	Q2GQG8 →
Q9ST62	—	0.955	Q9ST62 →
Q8R1S0	—	0.955	Q8R1S0 →
Q7S3C9	—	0.955	Q7S3C9 →
Q6Z836	—	0.955	Q6Z836 →
Q6DCP1	—	0.955	Q6DCP1 →
P0CU30	—	0.955	P0CU30 →
Q4WN75	—	0.955	Q4WN75 →
B0Y7C3	—	0.955	B0Y7C3 →
A1CT23	—	0.955	A1CT23 →
Q3TMV7	—	0.955	Q3TMV7 →
Q64323	—	0.954	Q64323 →
Q94AY1	—	0.954	Q94AY1 →
P52020	—	0.954	P52020 →
Q86PM2	—	0.954	Q86PM2 →
Q7Q6A7	—	0.954	Q7Q6A7 →
E0CTF3	—	0.954	E0CTF3 →