Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11344642 | 1.00 | SIGMAR1 (0.55) | SIGMAR1OPRK1CYP3A4CYP2D6TSHR | |
| SCHEMBL11454732 | 0.98 | SIGMAR1 (0.52) | SIGMAR1OPRK1CYP3A4CYP2D6TSHR | |
| SCHEMBL11454754 | 0.96 | SIGMAR1 (0.53) | SIGMAR1OPRK1CYP3A4CYP2D6TSHR | |
| SCHEMBL11348032 | 0.87 | SIGMAR1 (0.59) | SIGMAR1OPRK1CYP3A4CYP2D6TSHR | |
| SCHEMBL11447524 | 0.83 | SIGMAR1 (0.57) | SIGMAR1OPRK1CYP3A4CYP2D6TSHR | |
| SCHEMBL11331266 | 0.83 | SMN1; SMN2 (0.41) | SIGMAR1ALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL11332175 | 0.83 | SIGMAR1 (0.42) | SIGMAR1ALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL11546724 | 0.81 | MEN1 (0.40) | SIGMAR1ALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL11341323 | 0.81 | CNR2 (0.43) | SIGMAR1CYP3A4TSHRALDH1A1MEN1 | |
| SCHEMBL11334994 | 0.80 | MEN1 (0.45) | SIGMAR1OPRK1OPRM1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE30837-E | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1981-12-29 | — | — | US | disclosed |
| US-4199589-A | N-(2-Aminocycloheptyl)acylanilides and methods to treat depression | SZMUSZKOVICZ JACOB (US) | 1980-04-22 | — | — | US | disclosed |
| US-4172898-A | N-(2-aminocycloheptyl)acylanilides | THE UPJOHN COMPANY (US) | 1979-10-30 | — | — | US | disclosed |
| US-4169156-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-09-25 | — | — | US | disclosed |
| US-4159339-A | ANTIDEPRESSANTS | THE UPJOHN COMPANY (US) | 1979-06-26 | — | — | US | disclosed |
| US-4156014-A | N-(2-aminocycloheptyl)alkanoylanilides and in the treatment of depression | THE UPJOHN COMPANY (US) | 1979-05-22 | — | — | US | disclosed |