Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | HTR2C | P28335 | 4/20 | 0.43 |
| ▸ | HTR2B | P41595 | 4/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.42 |
| ▸ | PRCP | P42785 | 8/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11329553 | 1.00 | HTR2A (0.43) | HTR2AHTR2CHTR2BHRH3TMEM97 | |
| Hydrochloric Acid SCHEMBL11336226 | 0.99 | HTR2A (0.44) | HTR2AHTR2CHTR2BHRH3TMEM97 | |
| Hydrochloric Acid SCHEMBL11354739 | 0.97 | HTR2A (0.43) | HTR2AHTR2CHTR2BHRH3TMEM97 | |
| SCHEMBL11323825 | 0.91 | OPRD1 (0.46) | HTR2AHTR2CHTR2BHRH3TMEM97 | |
| SCHEMBL11323828 | 0.91 | OPRD1 (0.46) | HTR2AHTR2CHTR2BHRH3TMEM97 | |
| SCHEMBL11355116 | 0.90 | TMEM97 (0.42) | HTR2AHTR2CHTR2BHRH3TMEM97 | |
| SCHEMBL11355120 | 0.90 | TMEM97 (0.42) | HTR2AHTR2CHTR2BHRH3TMEM97 | |
| SCHEMBL11328342 | 0.89 | HTR2A (0.42) | HTR2AHTR2CHTR2BHRH3TMEM97 | |
| SCHEMBL11323073 | 0.89 | HTR2A (0.42) | HTR2AHTR2CHTR2BHRH3TMEM97 | |
| Hydrochloric Acid SCHEMBL11323987 | 0.89 | TMEM97 (0.42) | HTR2AHTR2CHTR2BHRH3TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4263317-A | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1981-04-21 | — | — | US | claimed |
| US-4301292-A | 1-[2-(4,5-Dihydro-4,4-dialkyl-2-oxazolyl)phenyl]-4-(dialkylamino)cyclohexanol | HOECHST-ROUSSEL PHARMACEUTICALS, INCORPORATED (US) | 1981-11-17 | — | — | US | disclosed |
| US-4292243-A | 3\"-Phenyldispiro[1,3-dioxolane-2,4'-cyclohexane-1',1\"-(3\"H)-isobenzofuran] | HOECHST ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1981-09-29 | — | — | US | disclosed |
| US-4292245-A | 3'-Phenylspiro[cyclohexane-1,1'(3'H)-isobenzofuran]-4-one | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1981-09-29 | — | — | US | disclosed |
| US-4290958-A | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1981-09-22 | — | — | US | disclosed |
| US-4288623-A | 1-Aryl-4-amino-cyclohexan-1-ols | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1981-09-08 | — | — | US | disclosed |
| US-4263317-A | Spiro[cyclohexane-1,1'(3'H)-isobenzofuran]s | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1981-04-21 | — | — | US | disclosed |