Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 5/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.42 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.42 |
| ▸ | MAP1LC3A | Q9H492 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098358 | 0.84 | FOLH1 (0.47) | FOLH1SLC7A5ANPEPENPEPMAP1LC3B | |
| SCHEMBL29478099 | 0.81 | SLC7A5 (0.49) | FOLH1SLC7A5ANPEPENPEPMAP1LC3B | |
| SCHEMBL30988817 | 0.81 | GSK3B (0.53) | GSK3BPTPN1FOLH1 | |
| SCHEMBL4054915 | 0.81 | SLC7A5 (0.49) | FOLH1SLC7A5ANPEPENPEPMAP1LC3B | |
| SCHEMBL4344951 | 0.81 | GSK3B (0.53) | GSK3BPTPN1FOLH1 | |
| SCHEMBL765921 | 0.81 | FOLH1 (0.61) | FOLH1ANPEPENPEP | |
| SCHEMBL11338354 | 0.80 | FOLH1 (0.41) | GSK3BFOLH1SLC7A5ANPEPENPEP | |
| SCHEMBL6844044 | 0.79 | FOLH1 (0.55) | FOLH1SLC7A5ANPEPENPEP | |
| SCHEMBL10019208 | 0.79 | FOLH1 (0.46) | FOLH1SLC7A5ANPEPENPEPMAP1LC3B | |
| SCHEMBL8094952 | 0.79 | FOLH1 (0.46) | FOLH1SLC7A5ANPEPENPEPMAP1LC3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0016277-B1 | 2-CARBONYL-3-HYDROXY-ALKENONITRILES, THEIR USE AS ANTI-ARTHRITIC AGENTS AND PROCESSES FOR THEIR PREPARATION | AMERICAN CYANAMID COMPANY (US) | 1981-12-02 | — | — | EP | disclosed |
| EP-0016277-A1 | 2-Carbonyl-3-hydroxy-alkenonitriles, their use as anti-arthritic agents and processes for their preparation | AMERICAN CYANAMID COMPANY (US) | 1980-10-01 | — | — | EP | disclosed |
| WO-1980000964-A1 | ANTI-INFLAMMATORY AGENTS INCLUDING 2-CARBONYL-3-HYDROXY-2-ALKENONITRILES | AMERICAN CYANAMID CO (US) | 1980-05-15 | — | — | WO | disclosed |
| US-4173650-A | ANTIARTHRITIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1979-11-06 | — | — | US | disclosed |
| US-4033978-A | Thiacycl[2.2.2]azine carboxylic acids | SYNTEX (U.S.A.) INC. (US) | 1977-07-05 | — | — | US | disclosed |