Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 8/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MPI | P34949 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15795636 | 0.89 | ZAP70 (0.49) | ZAP70JAK2 | |
| SCHEMBL15795376 | 0.89 | ZAP70 (0.55) | ZAP70KDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL15794955 | 0.83 | ZAP70 (0.58) | ZAP70ALK | |
| SCHEMBL11344864 | 0.81 | ZAP70 (0.56) | ZAP70SYKJAK2ALKEGFR | |
| SCHEMBL11331125 | 0.74 | JAK2 (0.38) | KDM4EMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL11441265 | 0.73 | CCND3 (0.48) | ZAP70MEN1MAPTKMT2ASYK | |
| SCHEMBL11296438 | 0.71 | WEE1 (0.44) | ZAP70SYKALK | |
| SCHEMBL11296289 | 0.71 | ALK (0.50) | JAK2ALKEGFR | |
| SCHEMBL1048459 | 0.70 | ZAP70 (1.00) | ZAP70SYKJAK2 | |
| SCHEMBL1047692 | 0.70 | ZAP70 (0.79) | ZAP70SYKJAK2ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665725-A1 | BICYCLIC INHIBITORS OF ALK | AbbVie Inc. (US) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012097683-A1 | BICYCLIC INHIBITORS OF ALK | ABBOTT LABORATORIES (US) | 2012-07-26 | — | — | WO | disclosed |