Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 13/20 | 0.56 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15795332 | 0.86 | ZAP70 (0.50) | ZAP70JAK2 | |
| SCHEMBL1049032 | 0.85 | ZAP70 (0.72) | ZAP70SYKJAK2 | |
| SCHEMBL11335352 | 0.81 | ZAP70 (0.54) | ZAP70ALKSYKJAK2EGFR | |
| SCHEMBL1048642 | 0.76 | ZAP70 (0.64) | ZAP70SYK | |
| SCHEMBL1048365 | 0.74 | ZAP70 (0.67) | ZAP70SYKJAK2 | |
| SCHEMBL1048551 | 0.73 | ZAP70 (0.80) | ZAP70JAK2EGFR | |
| SCHEMBL6521222 | 0.73 | ZAP70 (0.65) | ZAP70SYKJAK2EGFR | |
| SCHEMBL6521235 | 0.73 | ZAP70 (0.65) | ZAP70SYKJAK2EGFR | |
| SCHEMBL1044800 | 0.73 | ZAP70 (0.82) | ZAP70SYKJAK2 | |
| SCHEMBL1044792 | 0.72 | ZAP70 (1.00) | ZAP70SYKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2665725-A1 | BICYCLIC INHIBITORS OF ALK | AbbVie Inc. (US) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012097683-A1 | BICYCLIC INHIBITORS OF ALK | ABBOTT LABORATORIES (US) | 2012-07-26 | — | — | WO | disclosed |