Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4450648 | 0.86 | TSHR (0.56) | TSHRALDH1A1HSD17B10MAPK1TDP1 | |
| SCHEMBL28020518 | 0.83 | TSHR (0.65) | TSHRALDH1A1HSD17B10MAPK1TDP1 | |
| SCHEMBL11341203 | 0.79 | TSHR (0.59) | TSHRALDH1A1HSD17B10MAPK1TDP1 | |
| SCHEMBL22979125 | 0.79 | TSHR (0.62) | TSHRALDH1A1HSD17B10TDP1KDM4E | |
| SCHEMBL9959610 | 0.77 | TSHR (0.59) | TSHRALDH1A1HSD17B10MAPK1TDP1 | |
| SCHEMBL28974979 | 0.76 | TSHR (0.74) | TSHRALDH1A1HSD17B10MAPK1TDP1 | |
| SCHEMBL12768055 | 0.76 | TSHR (0.62) | TSHRALDH1A1HSD17B10MAPK1TDP1 | |
| SCHEMBL27796362 | 0.75 | TSHR (0.57) | TSHRALDH1A1HSD17B10MAPK1TDP1 | |
| SCHEMBL29678391 | 0.75 | TSHR (0.71) | TSHRALDH1A1HSD17B10TDP1KDM4E | |
| SCHEMBL873499 | 0.75 | TSHR (0.71) | TSHRALDH1A1HSD17B10TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4259338-A | Benzofuranyl-tetrahydropyridines and -piperidines, their acid addition salts and antidepressant preparations thereof | CIBA-GEIGY CORPORATION (US) | 1981-03-31 | — | — | US | disclosed |