Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 4/20 | 0.42 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.42 |
| ▸ | ENTPD3 | O75355 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10907979 | 0.93 | BRAF (0.42) | KDRLCKPOLBCA12CA1 | |
| SCHEMBL11349822 | 0.87 | TNNI3 (0.46) | KDRLCKMEN1KMT2APOLB | |
| SCHEMBL11340787 | 0.85 | PRMT1 (0.41) | KDRLCKMEN1KMT2APOLB | |
| SCHEMBL11339023 | 0.83 | CA12 (0.47) | KDRLCKMEN1KMT2APOLB | |
| SCHEMBL11419061 | 0.83 | TIMP3 (0.55) | KDRMEN1KMT2APOLBPRMT1 | |
| SCHEMBL11341037 | 0.83 | KMT2A (0.52) | KDRLCKMEN1KMT2APOLB | |
| SCHEMBL11344331 | 0.83 | HPSE (0.47) | KDRLCKMEN1KMT2APOLB | |
| SCHEMBL11345079 | 0.83 | HPSE (0.47) | KDRLCKMEN1KMT2APRMT1 | |
| SCHEMBL11347423 | 0.82 | TIMP3 (0.54) | MEN1KMT2ACA1CA2PRMT1 | |
| SCHEMBL10823354 | 0.82 | IDH1 (0.59) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4297372-A | ANTIARTHRITIC AGENTS; COLLAGENASE AND PROTEOLYTIC ENZYME INHIBITORS; BONE, SKIN, AND ORAL DISORDERS | AMERICAN CYANAMID COMPANY (US) | 1981-10-27 | — | — | US | disclosed |
| EP-0013784-A1 | C-Substituted naphthalenemonosulfonic ureides, process for their preparation and pharmaceutical compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |
| US-4216164-A | Ureide inhibitors of connective tissue destruction | AMERICAN CYANAMID COMPANY (US) | 1980-08-05 | — | — | US | disclosed |