Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.56 |
| ▸ | EGFR | P00533 | 16/20 | 0.56 |
| ▸ | CIT | O14578 | 2/20 | 0.55 |
| ▸ | GAK | O14976 | 2/20 | 0.55 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.55 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.55 |
| ▸ | STK17B | O94768 | 2/20 | 0.55 |
| ▸ | STK10 | O94804 | 2/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.55 |
| ▸ | ABL1 | P00519 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
| ▸ | LYN | P07948 | 2/20 | 0.55 |
| ▸ | RET | P07949 | 2/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.55 |
| ▸ | MET | P08581 | 2/20 | 0.55 |
| ▸ | HCK | P08631 | 2/20 | 0.55 |
| ▸ | FGR | P09769 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL175261 | 0.89 | EGFR (0.66) | BRAFERBB2EGFRCITGAK | |
| SCHEMBL29623541 | 0.89 | EGFR (0.66) | BRAFERBB2EGFRCITGAK | |
| SCHEMBL29623579 | 0.86 | EGFR (0.70) | ERBB2EGFRGAKMAPT | |
| SCHEMBL186338 | 0.86 | EGFR (0.70) | ERBB2EGFRGAKMAPT | |
| SCHEMBL185479 | 0.86 | EGFR (0.74) | BRAFERBB2EGFRCITGAK | |
| SCHEMBL29623589 | 0.86 | EGFR (0.74) | BRAFERBB2EGFRCITGAK | |
| SCHEMBL380507 | 0.83 | EGFR (0.66) | BRAFERBB2EGFRCITGAK | |
| Gefitinib SCHEMBL369686 | 0.83 | EGFR (0.80) | BRAFERBB2EGFRCITGAK | |
| SCHEMBL2762294 | 0.83 | EGFR (0.67) | BRAFERBB2EGFRCITGAK | |
| SCHEMBL1446518 | 0.83 | EGFR (0.70) | BRAFERBB2EGFRCITGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2326374-A1 | INHALER | Boehringer Ingelheim International GmbH (DE) | 2011-06-01 | — | — | EP | disclosed |
| EP-2285440-A2 | INHALER | Boehringer Ingelheim International GmbH (DE) | 2011-02-23 | — | — | EP | disclosed |
| WO-2009153049-A1 | INHALER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-12-23 | — | — | WO | disclosed |