Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 6/20 | 0.62 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NCK1 | P16333 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10412952 | 0.90 | CYP1A2 (0.60) | CYP1A2CYP2A6TDP1CA12CA9 | |
| SCHEMBL29837229 | 0.84 | CYP1A2 (0.87) | CYP1A2CYP2A6TDP1CA12CA9 | |
| SCHEMBL31612403 | 0.84 | CYP1A2 (0.87) | CYP1A2CYP2A6TDP1CA12CA9 | |
| SCHEMBL6891197 | 0.84 | CYP1A2 (0.87) | CYP1A2CYP2A6TDP1CA12CA9 | |
| SCHEMBL6056946 | 0.84 | CYP1A2 (0.87) | CYP1A2CYP2A6TDP1CA12CA9 | |
| SCHEMBL2490023 | 0.84 | CYP1A2 (0.87) | CYP1A2CYP2A6TDP1CA12CA9 | |
| SCHEMBL4368477 | 0.84 | CYP1A2 (0.87) | CYP1A2CYP2A6TDP1CA12CA9 | |
| SCHEMBL2463834 | 0.84 | CYP1A2 (0.87) | CYP1A2CYP2A6TDP1CA12CA9 | |
| SCHEMBL6888140 | 0.84 | CYP1A2 (0.87) | CYP1A2CYP2A6TDP1CA12CA9 | |
| SCHEMBL308248 | 0.79 | CYP1A2 (1.00) | CYP1A2CYP2A6TDP1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000154-B1 | NEW BENZ(F)ISOINDOLINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | SANDOZ AG (CH) | 1981-07-29 | — | — | EP | disclosed |