SCHEMBL11344972

SCHEMBL11344972

Cc1ccc2cc3c(cc2c1)CNC3

nearest known ligand 0.56

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 5/20 0.56
CYP2A6 P11509 4/20 0.56
TDP1 Q9NUW8 1/20 0.48
CA12 O43570 3/20 0.38
CA9 Q16790 3/20 0.38
ALDH1A1 P00352 2/20 0.35
LMNA P02545 2/20 0.35
NCK1 P16333 1/20 0.35
BACE1 P56817 1/20 0.35
KDM4E B2RXH2 1/20 0.35
GAA P10253 1/20 0.35
HPGD P15428 1/20 0.35
HSD17B10 Q99714 1/20 0.35
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
CHRNB2 P17787 1/20 0.33
CHRNA4 P43681 1/20 0.33
APEX1 P27695 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30560114 0.79 CHRNB2 (0.41) CYP1A2CYP2A6MEN1KMT2ACHRNB2
SCHEMBL5068876 0.79 CHRNB2 (0.41) CYP1A2CYP2A6MEN1KMT2ACHRNB2
Hydrochloric Acid SCHEMBL3118573 0.77 CHRNB2 (0.39) CYP1A2CYP2A6MEN1KMT2ACHRNB2
SCHEMBL28692154 0.76 CYP2A6 (0.59) CYP1A2CYP2A6TDP1CA12CA9
SCHEMBL6888140 0.75 CYP1A2 (0.87) CYP1A2CYP2A6TDP1CA12CA9
SCHEMBL4368477 0.75 CYP1A2 (0.87) CYP1A2CYP2A6TDP1CA12CA9
SCHEMBL6056946 0.75 CYP1A2 (0.87) CYP1A2CYP2A6TDP1CA12CA9
SCHEMBL2490023 0.75 CYP1A2 (0.87) CYP1A2CYP2A6TDP1CA12CA9
SCHEMBL31612403 0.75 CYP1A2 (0.87) CYP1A2CYP2A6TDP1CA12CA9
SCHEMBL2463834 0.75 CYP1A2 (0.87) CYP1A2CYP2A6TDP1CA12CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0000154-B1 NEW BENZ(F)ISOINDOLINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM SANDOZ AG (CH) 1981-07-29 EP disclosed