SCHEMBL11348442

SCHEMBL11348442

COC(=O)c1ccc(CCc2ccccc2OCCCCN(C)C)cc1

nearest known ligand 0.69

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 2/20 0.49
KDM4E B2RXH2 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11251658 0.88 PTGER1 (0.57) HRH1KDM4E
SCHEMBL11249089 0.88 CYP4F2 (0.50) HRH1KDM4E
SCHEMBL11259979 0.84 KDM4E (0.51) HRH1KDM4E
SCHEMBL8409671 0.84 ABCB1 (0.51)
SCHEMBL11253611 0.82 HRH1 (0.68) HRH1
SCHEMBL11266783 0.81 HRH1 (0.56) HRH1KDM4E
SCHEMBL11260191 0.81 HRH1 (0.56) HRH1
SCHEMBL11260136 0.81 HRH1 (0.67) HRH1
SCHEMBL11254706 0.81 HRH1 (0.67) HRH1
SCHEMBL11257755 0.81 HRH1 (0.67) HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0001759-B1 (OMEGA-AMINOALKOXY) BIBENZYLS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE SUBSTANCES MITSUBISHI KASEI CORPORATION (JP) 1981-12-30 EP disclosed
US-4220603-A ANTICOAGULANTS MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) 1980-09-02 US disclosed
EP-0001759-A1 (Omega-aminoalkoxy) bibenzyls, processes for their preparation and pharmaceutical compositions containing these substances MITSUBISHI KASEI CORPORATION (JP) 1979-05-16 EP disclosed