Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | KMO | O15229 | 2/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.46 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.46 |
| ▸ | GALR3 | O60755 | 1/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL248214 | 0.87 | RECQL (1.00) | RECQLTDP1ADRA2ACYP1A2KMO | |
| SCHEMBL30346162 | 0.87 | RECQL (1.00) | RECQLTDP1ADRA2ACYP1A2KMO | |
| SCHEMBL9917434 | 0.85 | RECQL (0.75) | RECQLTDP1ADRA2ACYP1A2KMO | |
| SCHEMBL5530473 | 0.85 | RECQL (0.75) | RECQLADRA2ACYP1A2KMORAB9A | |
| SCHEMBL27839410 | 0.85 | RECQL (0.75) | RECQLTDP1ADRA2ACYP1A2KMO | |
| SCHEMBL24041809 | 0.85 | RECQL (0.75) | RECQLTDP1ADRA2ACYP1A2KMO | |
| SCHEMBL29459664 | 0.85 | RECQL (0.75) | RECQLADRA2ACYP1A2KMORAB9A | |
| SCHEMBL4831197 | 0.85 | RECQL (0.75) | RECQLTDP1ADRA2ACYP1A2KMO | |
| SCHEMBL19675505 | 0.83 | RECQL (0.77) | RECQLTDP1ADRA2ACYP1A2KMO | |
| SCHEMBL9917342 | 0.83 | KMO (0.57) | RECQLTDP1KMOTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2285783-A1 | INDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2011-02-23 | — | — | EP | disclosed |