Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3439292 | 1.00 | SLC22A6 (0.42) | SLC22A6LDHASRRGABRR1LMNA | |
| SCHEMBL2227119 | 1.00 | SLC22A6 (0.42) | SLC22A6LDHASRRGABRR1LMNA | |
| SCHEMBL1405707 | 0.79 | — | — | |
| SCHEMBL30972500 | 0.79 | — | — | |
| SCHEMBL2687087 | 0.79 | — | — | |
| SCHEMBL374298 | 0.79 | — | — | |
| SCHEMBL14212308 | 0.79 | KDM4E (0.38) | TSHRCA1CA2CA9 | |
| SCHEMBL4669398 | 0.78 | SLC22A6 (0.43) | SLC22A6LDHASRRGABRR1LMNA | |
| SCHEMBL1135942 | 0.78 | SLC22A6 (0.43) | SLC22A6LDHASRRGABRR1LMNA | |
| Bicarbonate SCHEMBL17054410 | 0.77 | SLC22A6 (0.63) | SLC22A6GABRR1LMNATSHRCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 91 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107653238-B | Carbonyl reductase gene engineering bacterium immobilized cell and application thereof | 浙江工业大学 | 2021-05-11 | — | — | CN | claimed |
| CN-109295019-B | Alcohol dehydrogenase mutant and application thereof | 浙江大学 | 2021-01-12 | — | — | CN | claimed |
| CN-111647591-A | Method for preparing statin intermediate by using immobilized enzyme | 湖州颐盛生物科技有限公司 | 2020-09-11 | — | — | CN | claimed |
| US-10724008-B2 | Ketoreductases | C-LECTA GMBH (DE) | 2020-07-28 | — | — | US | claimed |
| EP-3134519-B1 | KETOREDUCTASES | C LECTA GMBH (DE) | 2018-06-06 | — | — | EP | claimed |
| US-20170218345-A1 | KETOREDUCTASES | C-LECTA GMBH (DE) | 2017-08-03 | — | — | US | claimed |
| EP-3134519-A1 | KETOREDUCTASES | c-LEcta GmbH (DE) | 2017-03-01 | — | — | EP | claimed |
| US-9228214-B2 | Process for the enantioselective enzymatic reduction of hydroxy keto compounds | CAMBREX IEP GMBH (DE) | 2016-01-05 | — | — | US | claimed |
| WO-2015162064-A1 | KETOREDUCTASES | C-LECTA GMBH (DE) | 2015-10-29 | — | — | WO | claimed |
| US-20150152451-A1 | PROCESS FOR THE ENANTIOSELECTIVE ENZYMATIC REDUCTION OF HYDROXY KETO COMPOUNDS | CAMBREX IEP GMBH (DE) | 2015-06-04 | — | — | US | claimed |
| US-8980592-B2 | Process for the enantioselective enzymatic reduction of hydroxy keto compounds | CAMBREX IEP GMBH (DE) | 2015-03-17 | — | — | US | claimed |
| EP-1963516-B1 | METHOD FOR THE ENANTIOSELECTIVE ENZYMATIC REDUCTION OF HYDROXYKETO COMPOUNDS | IEP GMBH (DE) | 2011-02-23 | — | — | EP | claimed |
| US-20090221044-A1 | Process for the Enantioselective Enzymatic Reduction of Hydroxy Keto Compounds | IEP GMBH (DE) | 2009-09-03 | — | — | US | claimed |
| CN-101432435-A | Method for the enantioselective enzymatic reduction of hydroxyketo compounds | IEP GMBH (DE) | 2009-05-13 | — | — | CN | claimed |
| EP-1963516-A1 | METHOD FOR THE ENANTIOSELECTIVE ENZYMATIC REDUCTION OF HYDROXYKETO COMPOUNDS | IEP GmbH (DE) | 2008-09-03 | — | — | EP | claimed |
| WO-2007073875-A1 | METHOD FOR THE ENANTIOSELECTIVE ENZYMATIC REDUCTION OF HYDROXYKETO COMPOUNDS | IEP GMBH (DE) | 2007-07-05 | — | — | WO | claimed |
| EP-1152054-B1 | NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME | KANEKA CORP (JP) | 2005-03-23 | — | — | EP | claimed |
| US-6645746-B1 | Expression vector; transformants; E. coli; Candida; Bacillus; use of microorganisms to produce t-butyl(3R,5S)-6-chloro-3,5 -dihydroxyhexanoate, by enzymatic asymmetrical reduction, for drug, pesticide and HMG-CoA reductase inhibitor synthesis | KANEKA CORPORATION (JP) | 2003-11-11 | — | — | US | claimed |
| EP-1152054-A1 | NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME | Kaneka Corporation (JP) | 2001-11-07 | — | — | EP | claimed |
| CN-117904066-A | Recombinant carbonyl reductase mutant and application thereof in catalytic synthesis of chiral alcohol | 浙江工业大学 | 2024-04-19 | — | — | CN | disclosed |
| CN-114436834-A | Method for synthesizing rosuvastatin calcium intermediate by using continuous flow microchannel reactor | 江苏阿尔法药业股份有限公司 | 2022-05-06 | — | — | CN | disclosed |
| CN-110423741-B | Carbonyl reductase-coenzyme NADP+Co-immobilized enzyme and preparation and application thereof | 浙江工业大学 | 2021-08-17 | — | — | CN | disclosed |
| CN-107779459-B | Glucose dehydrogenase DNA molecule, vector, strain and application | 安琪酵母股份有限公司 | 2021-06-08 | — | — | CN | disclosed |
| CN-107653238-B | Carbonyl reductase gene engineering bacterium immobilized cell and application thereof | 浙江工业大学 | 2021-05-11 | — | — | CN | disclosed |
| CN-110106130-B | Transaminase-coenzyme co-immobilized engineering bacteria cell and application thereof | 浙江工业大学 | 2021-05-04 | — | — | CN | disclosed |
| CN-110387359-B | Carbonyl reductase mutant and application thereof | 湖州颐盛生物科技有限公司 | 2021-04-20 | — | — | CN | disclosed |
| CN-110387359-B | Carbonyl reductase mutant and application thereof | 湖州颐盛生物科技有限公司 | 2021-04-20 | — | — | CN | disclosed |
| CN-107794270-B | Ketone reductase DNA molecule, recombinant vector, strain and application | 安琪酵母股份有限公司 | 2021-02-02 | — | — | CN | disclosed |
| CN-109295019-B | Alcohol dehydrogenase mutant and application thereof | 浙江大学 | 2021-01-12 | — | — | CN | disclosed |
| CN-109295019-B | Alcohol dehydrogenase mutant and application thereof | 浙江大学 | 2021-01-12 | — | — | CN | disclosed |
| CN-108486075-B | Recombinant carbonyl reductase mutant, gene, engineering bacterium and application thereof | 浙江工业大学 | 2020-11-13 | — | — | CN | disclosed |
| CN-107058251-B | Recombinant carbonyl reductase mutant, gene, vector, engineering bacterium and application thereof | 浙江工业大学 | 2020-10-09 | — | — | CN | disclosed |
| CN-111647591-A | Method for preparing statin intermediate by using immobilized enzyme | 湖州颐盛生物科技有限公司 | 2020-09-11 | — | — | CN | disclosed |
| CN-111647591-A | Method for preparing statin intermediate by using immobilized enzyme | 湖州颐盛生物科技有限公司 | 2020-09-11 | — | — | CN | disclosed |
| US-10724008-B2 | Ketoreductases | C-LECTA GMBH (DE) | 2020-07-28 | — | — | US | disclosed |
| US-10093905-B2 | Ketoreductases | C-LECTA GMBH (DE) | 2018-10-09 | — | — | US | disclosed |
| CN-108486075-A | A kind of recombination carbonyl reduction enzyme mutant, gene, engineering bacteria and its application | 浙江工业大学 | 2018-09-04 | — | — | CN | disclosed |
| EP-3134519-B1 | KETOREDUCTASES | C LECTA GMBH (DE) | 2018-06-06 | — | — | EP | disclosed |
| US-20170218345-A1 | KETOREDUCTASES | C-LECTA GMBH (DE) | 2017-08-03 | — | — | US | disclosed |
| EP-2890810-B1 | SENSOR FOR NADP (H) AND DEVELOPMENT OF ALCOHOL DEHYDROGENASES | FORSCHUNGSZENTRUM JUELICH GMBH (DE) | 2017-08-02 | — | — | EP | disclosed |
| EP-3134519-A1 | KETOREDUCTASES | c-LEcta GmbH (DE) | 2017-03-01 | — | — | EP | disclosed |
| US-9228214-B2 | Process for the enantioselective enzymatic reduction of hydroxy keto compounds | CAMBREX IEP GMBH (DE) | 2016-01-05 | — | — | US | disclosed |
| CN-105087685-A | Method for synthesizing (3R,5S)-6-chloro-3,5-dihydroxyhexanoate | LIANYUNGANG HONGYE CHEMICAL CO LTD | 2015-11-25 | — | — | CN | disclosed |
| WO-2015162064-A1 | KETOREDUCTASES | C-LECTA GMBH (DE) | 2015-10-29 | — | — | WO | disclosed |
| EP-2890810-A1 | SENSOR FOR NADP (H) AND DEVELOPMENT OF ALCOHOL DEHYDROGENASES | Forschungszentrum Jülich GmbH (DE) | 2015-07-08 | — | — | EP | disclosed |
| CN-104726506-A | Preparation method of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate | ENZYMEWORKS INC | 2015-06-24 | — | — | CN | disclosed |
| US-20150152451-A1 | PROCESS FOR THE ENANTIOSELECTIVE ENZYMATIC REDUCTION OF HYDROXY KETO COMPOUNDS | CAMBREX IEP GMBH (DE) | 2015-06-04 | — | — | US | disclosed |
| CN-104651290-A | Engineering bacterium and application thereof in preparation of atorvastatin drug intermediate | UNIV ZHEJIANG | 2015-05-27 | — | — | CN | disclosed |
| US-8980592-B2 | Process for the enantioselective enzymatic reduction of hydroxy keto compounds | CAMBREX IEP GMBH (DE) | 2015-03-17 | — | — | US | disclosed |
| CN-104328148-A | Method for preparing tert-butyl (3R, 5S)-6-chloro-3,5-dihydroxy hexanoate by using enzymatic method | SYNCOZYMES SHANGHAI CO LTD | 2015-02-04 | — | — | CN | disclosed |
| WO-2014203045-A1 | A NOVEL, GREEN AND COST EFFECTIVE PROCESS FOR SYNTHESIS OF TERT-BUTYL (3R,5S)-6-OXO-3,5-DIHYDROXY-3,5-O-ISOPROPYLIDENE-HEXANOATE | LUPIN LIMITED (IN) | 2014-12-24 | — | — | WO | disclosed |
| WO-2014032777-A1 | SENSOR FOR NADP (H) AND DEVELOPMENT OF ALCOHOL DEHYDROGENASES | Forschungszentrum Jülich GmbH (DE) | 2014-03-06 | — | — | WO | disclosed |
| CN-103483195-A | Preparation method of tert-butyl (3R,5S)-6-chloro-3,5-dihydroxyhexanoate | Huanggang huayang pharmaceutical co ltd | 2014-01-01 | — | — | CN | disclosed |
| EP-1963516-B1 | METHOD FOR THE ENANTIOSELECTIVE ENZYMATIC REDUCTION OF HYDROXYKETO COMPOUNDS | IEP GMBH (DE) | 2011-02-23 | — | — | EP | disclosed |
| EP-1619191-B1 | Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl] acetic acid derivatives | KANEKA CORP (JP) | 2010-10-27 | — | — | EP | disclosed |
| US-20090221044-A1 | Process for the Enantioselective Enzymatic Reduction of Hydroxy Keto Compounds | IEP GMBH (DE) | 2009-09-03 | — | — | US | disclosed |
| EP-1583730-B1 | NOVEL PROCESS FOR PREPARING A 5-HYDROXY-3-OXO-HEXANOIC ACID DERIVATIVE | LG LIFE SCIENCES LTD (KR) | 2009-08-05 | — | — | EP | disclosed |
| CN-101432435-A | Method for the enantioselective enzymatic reduction of hydroxyketo compounds | IEP GMBH (DE) | 2009-05-13 | — | — | CN | disclosed |
| EP-1963516-A1 | METHOD FOR THE ENANTIOSELECTIVE ENZYMATIC REDUCTION OF HYDROXYKETO COMPOUNDS | IEP GmbH (DE) | 2008-09-03 | — | — | EP | disclosed |
| EP-1394157-B1 | Process for the preparation of 3,5-dihydroxy substituted esters as intermediates for producing optically active 2-(6-(hydroxymethyl)-1,3-dioxan-4-yl) acetic acid dervatives | KANEKA CORP (JP) | 2007-10-17 | — | — | EP | disclosed |
| WO-2007073875-A1 | METHOD FOR THE ENANTIOSELECTIVE ENZYMATIC REDUCTION OF HYDROXYKETO COMPOUNDS | IEP GMBH (DE) | 2007-07-05 | — | — | WO | disclosed |
| US-RE39333-E1 | Process for the preparation of 5-hydroxy-3-oxopentanoic acid derivatives | KANEKA CORPORATION (JP) | 2006-10-10 | — | — | US | disclosed |
| EP-1583730-A4 | NOVEL PROCESS FOR PREPARING A 5-HYDROXY-3-OXO-HEXANOIC ACID DERIVATIVE | LG LIFE SCIENCES LTD (KR) | 2006-08-09 | — | — | EP | disclosed |
| US-7081546-B2 | Blaise reaction of optionally OH-protected S)-4-halo-3-hydroxybutyronitrile with haloacetate in the presence of zinc metal activated by an organic acid to prepare a 5-hydroxy-3-oxo-hexanoic aicid derivative or its tautomer and hydrolyzing to remove protecting group (e.g., trisubstituted silyl) | LG LIFE SCIENCES LTD. (KR) | 2006-07-25 | — | — | US | disclosed |
| US-20060079710-A1 | Novel process for preparing a 5-hydroxy-3-oxo-hexanoic acid derivative | LG LIFE SCIENCES LTD. (KR) | 2006-04-13 | — | — | US | disclosed |
| EP-1619191-A2 | Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl] acetic acid derivatives | KANEKA CORPORATION (JP) | 2006-01-25 | — | — | EP | disclosed |
| EP-1583730-A1 | NOVEL PROCESS FOR PREPARING A 5-HYDROXY-3-OXO-HEXANOIC ACID DERIVATIVE | LG Life Sciences Ltd. (KR) | 2005-10-12 | — | — | EP | disclosed |
| US-6903225-B2 | Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives | KANEKA CORPORATION (JP) | 2005-06-07 | — | — | US | disclosed |
| EP-1152054-B1 | NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME | KANEKA CORP (JP) | 2005-03-23 | — | — | EP | disclosed |
| EP-1152054-B1 | NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME | KANEKA CORP (JP) | 2005-03-23 | — | — | EP | disclosed |
| WO-2004063132-A1 | NOVEL PROCESS FOR PREPARING A 5-HYDROXY-3-OXO-HEXANOIC ACID DERIVATIVE | LG LIFE SCIENCES LTD. (KR) | 2004-07-29 | — | — | WO | disclosed |
| EP-1024139-B1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2-(6-(HYDROXYMETHYL)-1,3-DIOXAN-4-YL) ACETIC ACID DERIVATIVES | KANEKA CORP (JP) | 2004-05-12 | — | — | EP | disclosed |
| EP-1104750-B1 | PROCESSES FOR THE PREPARATION OF 5-HYDROXY-3-OXOPENTANOIC ACID DERIVATIVES | KANEKA CORP (JP) | 2004-04-14 | — | — | EP | disclosed |
| EP-1394157-A2 | Process for the preparation of 3,5-dihydroxy substituted esters as intermediates for producing optically active 2-(6-(hydroxymethyl)-1,3-dioxan-4-yl) acetic acid dervatives | KANEKA CORPORATION (JP) | 2004-03-03 | — | — | EP | disclosed |
| US-6645746-B1 | Expression vector; transformants; E. coli; Candida; Bacillus; use of microorganisms to produce t-butyl(3R,5S)-6-chloro-3,5 -dihydroxyhexanoate, by enzymatic asymmetrical reduction, for drug, pesticide and HMG-CoA reductase inhibitor synthesis | KANEKA CORPORATION (JP) | 2003-11-11 | — | — | US | disclosed |
| US-6645746-B1 | Expression vector; transformants; E. coli; Candida; Bacillus; use of microorganisms to produce t-butyl(3R,5S)-6-chloro-3,5 -dihydroxyhexanoate, by enzymatic asymmetrical reduction, for drug, pesticide and HMG-CoA reductase inhibitor synthesis | KANEKA CORPORATION (JP) | 2003-11-11 | — | — | US | disclosed |
| WO-2003072793-A2 | METHOD FOR PRODUCING ALCOHOLS FROM SUBSTRATES BY USING OXIDE REDUCTASES, TWO-PHASE SYSTEM COMPRISING AN AQUEOUS PHASE AND AN ORGANIC PHASE AND DEVICE FOR CARRYING OUT SAID METHOD | Forschungszentrum Jülich GmbH (DE) | 2003-09-04 | — | — | WO | disclosed |
| US-20030040634-A1 | Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4yl]acetic acid derivatives | KANEKA CORPORATION (JP) | 2003-02-27 | — | — | US | disclosed |
| EP-1152054-A4 | NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME | KANEKA CORP (JP) | 2002-11-20 | — | — | EP | disclosed |
| US-6472544-B1 | REACTING ACETIC ACID DERIVATIVE WITH AN ENOLATE, REDUCING WITH A MICROORGANISM, ACETALIZING IN PRESENCE OF ACID CATALYST THEN ALKALINE SAPONIFICATION; NO SPECIAL EQUIPMENT OR SUPER LOW TEMPERATURE REQUIRED; INEXPENSIVE STARTING MATERIALS | KANEKA CORPORATION (JP) | 2002-10-29 | — | — | US | disclosed |
| US-6340767-B1 | REACTION OF LITHIUM AMIDE WITH ACETIC ACID ESTER AND HYDROXY PROPIONIC ACID | KANEKA CORPORATION (JP) | 2002-01-22 | — | — | US | disclosed |
| EP-1152054-A1 | NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME | Kaneka Corporation (JP) | 2001-11-07 | — | — | EP | disclosed |
| EP-1152054-A1 | NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME | Kaneka Corporation (JP) | 2001-11-07 | — | — | EP | disclosed |
| EP-1141373-A1 | METHOD FOR THE ENANTIOSELECTIVE REDUCTION OF 3,5-DIOXOCARBOXYLIC ACIDS, THEIR SALTS AND THEIR ESTERS | FORSCHUNGSZENTRUM JÜLICH GMBH (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2001040450-A1 | NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME | KANEKA CORPORATION (JP) | 2001-06-07 | — | — | WO | disclosed |
| EP-1104750-A1 | PROCESSES FOR THE PREPARATION OF 5-HYDROXY-3-OXOPENTANOIC ACID DERIVATIVES | KANEKA CORPORATION (JP) | 2001-06-06 | — | — | EP | disclosed |
| EP-1024139-A1 | PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE 2- 6-(HYDROXYMETHYL)-1,3-DIOXAN-4-YL]ACETIC ACID DERIVATIVES | KANEKA CORPORATION (JP) | 2000-08-02 | — | — | EP | disclosed |
| WO-2000036134-A1 | METHOD FOR THE ENANTIOSELECTIVE REDUCTION OF 3,5-DIOXOCARBOXYLIC ACIDS, THEIR SALTS AND THEIR ESTERS | Forschungszentrum Jülich GmbH (DE) | 2000-06-22 | — | — | WO | disclosed |
| US-5594153-A | REACTING 6-HALO-3,5-DIHYDROXYHEXANOIC ACID OR DERIVATIVE THEREOF WITH DIETHER, KETONE OR UNSATURATED ETHER TO FORM 1,3-DIOXANE DERIVATIVE | E. R. SQUIBB & SONS, INC. (US) | 1997-01-14 | — | — | US | disclosed |
| US-5457227-A | Condensing halo-substituted hydroxy ester with acetic acid, acetate salt or ester in presence of condensation agent to produce halo-substituted hydroxy keto ester | E. R. SQUIBB & SONS, INC. (US) | 1995-10-10 | — | — | US | disclosed |
| US-5278313-A | Chemical condensation reaction | E. R. SQUIBB & SONS, INC. (US) | 1994-01-11 | — | — | US | disclosed |
| US-5278313-A | Chemical condensation reaction | E. R. SQUIBB & SONS, INC. (US) | 1994-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030040634-A1 | Process for producing optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4yl]acetic acid derivatives | HAAO, APEH, AADAC | SLC22A6 2542/4885LDHA 715/4885SRR 605/4885 |
| US-20060079710-A1 | Novel process for preparing a 5-hydroxy-3-oxo-hexanoic acid derivative | HMGCR, CYP8B1, CYP4A11 | SLC22A6 2056/4885LDHA 294/4885SRR 326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.