Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.60 |
| ▸ | HRH1 | P35367 | 2/20 | 0.60 |
| ▸ | HTR6 | P50406 | 2/20 | 0.60 |
| ▸ | DRD2 | P14416 | 2/20 | 0.60 |
| ▸ | DRD4 | P21917 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.60 |
| ▸ | DRD1 | P21728 | 1/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
| ▸ | HTR2B | P41595 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11369932 | 0.89 | HTR6 (0.60) | CHRM2HRH1HTR6DRD2DRD4 | |
| Maleic Acid SCHEMBL11365197 | 0.88 | HRH2 (0.67) | CHRM2HRH1HTR6DRD2DRD4 | |
| Maleic Acid SCHEMBL11364479 | 0.88 | HRH2 (0.67) | CHRM2HRH1HTR6DRD2DRD4 | |
| SCHEMBL11367749 | 0.88 | HTR2C (0.82) | CHRM2HRH1HTR6DRD2DRD4 | |
| SCHEMBL11373476 | 0.88 | HTR2C (0.82) | CHRM2HRH1HTR6DRD2DRD4 | |
| Maleic Acid SCHEMBL11370510 | 0.88 | HRH2 (0.67) | CHRM2HRH1HTR6DRD2DRD4 | |
| SCHEMBL1146217 | 0.88 | HTR2A (0.73) | CHRM2HRH1HTR6DRD2DRD4 | |
| SCHEMBL12856888 | 0.88 | HTR2A (0.73) | CHRM2HRH1HTR6DRD2DRD4 | |
| SCHEMBL4253544 | 0.88 | HTR2A (0.73) | CHRM2HRH1HTR6DRD2DRD4 | |
| SCHEMBL12072060 | 0.88 | HTR2A (0.73) | CHRM2HRH1HTR6DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4154836-A | DEPRESSANT, ANTIHISTAMINE, ANTISEROTININE, NEUROLEPTIC | AKZONA INCORPORATED (US) | 1979-05-15 | — | — | US | claimed |
| US-4271178-A | 1,2,3,3a,8,12b-Hexahydro-dibenzo[b,f]pyrrolo[3,4-d]azepines and pharmaceutical use thereof | AKZONA INCORPORATED (US) | 1981-06-02 | — | — | US | disclosed |
| US-4271179-A | 1,2,3,3a,8,12b-Hexahydro-dibenzo[1,2;5,6]cyclohepta[3,4-C]pyrroles and pharmaceutical use thereof | AKZONA INCORPORATED (US) | 1981-06-02 | — | — | US | disclosed |
| US-4271177-A | 2,3,3a,12b-Tetrahydro-1H-dibenzo[2,3;6,7]thiepino[4,5-c]pyrroles and pharmaceutical use thereof | AKZONA INCORPORATED (US) | 1981-06-02 | — | — | US | disclosed |
| US-4177275-A | Tension reducing 2,3,4,4a,9,13b-hexahydro-1H-dibenzo[b,f]pyrido[3,4-d]azepine derivatives | AKZONA INC. (US) | 1979-12-04 | — | — | US | disclosed |
| US-4158058-A | DEPRESSANTS; ANTIHISTAMINES; ANTISEROTONINE AGENTS | AKZONA INCORPORATED (US) | 1979-06-12 | — | — | US | disclosed |
| US-4158059-A | Tension reducing 2,3,4,4a,9,136-hexahydro-dibenz[1,2;5,6]cyclohepta[3,4-c]py | AKZONA INCORPORATED (US) | 1979-06-12 | — | — | US | disclosed |
| US-4154836-A | DEPRESSANT, ANTIHISTAMINE, ANTISEROTININE, NEUROLEPTIC | AKZONA INCORPORATED (US) | 1979-05-15 | — | — | US | disclosed |