Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.53 |
| ▸ | RAD52 | P43351 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | USP2 | O75604 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | BLM | P54132 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5470276 | 0.98 | KMT2A (0.55) | KMT2ARXFP1RAD52HTR2CMEN1 | |
| SCHEMBL2346449 | 0.94 | KMT2A (0.52) | KMT2ARXFP1RAD52HTR2CMEN1 | |
| SCHEMBL11223239 | 0.79 | KMT2A (0.59) | KMT2ARXFP1RAD52HTR2CMEN1 | |
| SCHEMBL13503134 | 0.76 | KMT2A (0.55) | KMT2ARXFP1RAD52HTR2CMEN1 | |
| SCHEMBL2269084 | 0.76 | KMT2A (0.60) | KMT2ARXFP1RAD52HTR2CMEN1 | |
| SCHEMBL15721662 | 0.76 | KMT2A (0.55) | KMT2ARXFP1RAD52HTR2CMEN1 | |
| SCHEMBL11507401 | 0.76 | KMT2A (0.55) | KMT2ARXFP1RAD52HTR2CMEN1 | |
| SCHEMBL20115140 | 0.76 | KMT2A (0.55) | KMT2ARXFP1RAD52HTR2CMEN1 | |
| SCHEMBL14366798 | 0.74 | KMT2A (0.53) | KMT2ARXFP1RAD52HTR2CMEN1 | |
| SCHEMBL13019566 | 0.74 | KMT2A (0.53) | KMT2ARXFP1RAD52HTR2CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4283537-A | Thiazine-1,1-dioxide and isothiazole-1,1-dioxide derivatives and process for preparation | POLAROID CORPORATION (US) | 1981-08-11 | — | — | US | disclosed |
| US-4259493-A | INDICATOR DYES OR PHOTOGRAPHIC LIGHT-SCREENING DYES | POLAROID CORPORATION (US) | 1981-03-31 | — | — | US | disclosed |
| US-4210752-A | Synthesis of substituted sulfam(na)phthaleins | POLAROID CORPORATION (US) | 1980-07-01 | — | — | US | disclosed |
| US-4186001-A | IRREVERSIBLE CLEAVAGE IN ALKALINE SOLUTION TO FORM COLORLESS COMPOUND | POLAROID CORPORATION (US) | 1980-01-29 | — | — | US | disclosed |
| US-4140689-A | 3-(Julolidinyl)-benz[d]isothiazole-1,1-dioxide | POLAROID CORPORATION (US) | 1979-02-20 | — | — | US | disclosed |