Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL114787 | 0.87 | FAAH (0.41) | PIK3CAHRH1HRH4FAAHPIK3CD | |
| SCHEMBL115367 | 0.87 | PIK3CA (0.49) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL115817 | 0.87 | IDO1 (0.41) | PIK3CAHRH1HRH4FAAHPIK3CD | |
| SCHEMBL114964 | 0.80 | AVPR1B (0.38) | PIK3CASIGMAR1 | |
| SCHEMBL3099239 | 0.74 | PIK3CA (0.37) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL114963 | 0.74 | PIK3CA (0.46) | PIK3CAMTOR | |
| SCHEMBL165835 | 0.73 | PIK3CA (0.47) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL115606 | 0.73 | PIK3CA (0.47) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 | |
| SCHEMBL116034 | 0.73 | PIK3CA (0.43) | PIK3CAHRH1HRH4FAAHPIK3CD | |
| SCHEMBL115836 | 0.73 | PIK3CA (0.73) | PIK3CAPIK3CDPIK3CBPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | Amgen, Inc (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126895-A1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC. (US) | 2010-11-04 | — | — | WO | disclosed |