SCHEMBL11366372

SCHEMBL11366372

Cc1ccsc1-c1ncns1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 8/20 0.43
CYP3A4 P08684 4/20 0.42
CYP2C19 P33261 4/20 0.42
CYP2B6 P20813 2/20 0.42
CYP2D6 P10635 2/20 0.40
CYP2C9 P11712 2/20 0.40
CYP2E1 P05181 1/20 0.40
NISCH Q9Y2I1 1/20 0.39
ALDH1A1 P00352 5/20 0.36
HPGD P15428 2/20 0.36
KDM4E B2RXH2 4/20 0.33
CYP1A2 P05177 2/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
HTT P42858 1/20 0.33
RECQL P46063 1/20 0.33
LMNA P02545 2/20 0.32
MAPT P10636 1/20 0.32
APOBEC3G Q9HC16 1/20 0.32
ESR1 P03372 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL722595 0.71 CYP2A6 (0.56) CYP2A6CYP3A4CYP2C19CYP2B6CYP2D6
SCHEMBL18783296 0.68 CYP2A6 (0.50) CYP2A6CYP3A4CYP2C19CYP2B6CYP2D6
SCHEMBL10301441 0.68 CYP2A6 (0.46) CYP2A6CYP3A4CYP2C19CYP2B6CYP2D6
SCHEMBL1181150 0.67 PDE10A (0.44) CYP2A6CYP3A4CYP2C19CYP2B6CYP2D6
SCHEMBL14886177 0.65 CYP2A6 (0.52) CYP2A6CYP3A4CYP2C19CYP2B6CYP2D6
SCHEMBL679998 0.65 CYP2A6 (0.43) CYP2A6CYP3A4CYP2C19CYP2B6CYP2D6
SCHEMBL14038764 0.65 CYP2A6 (0.47) CYP2A6CYP3A4CYP2C19CYP2B6CYP2D6
SCHEMBL13130594 0.65 CYP2A6 (0.61) CYP2A6CYP3A4CYP2C19CYP2B6CYP2D6
SCHEMBL9825986 0.64 COMT (0.45) CYP2A6CYP3A4CYP2C19CYP2B6CYP2D6
SCHEMBL18783025 0.64 ALDH1A1 (0.53) CYP2A6CYP3A4CYP2C19CYP2B6CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0022245-A2 Aminothiadiazolyl derivatives, process for their preparation, pharmaceutical compositions containing them;starting compounds and process for their preparation CIBA-GEIGY AG (CH) 1981-01-14 EP disclosed
US-4118562-A ANTIBIOTICS YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 1978-10-03 US disclosed
US-4093804-A ANTIBIOTICS YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) 1978-06-06 US disclosed
US-4093802-A ANTIBIOTICS YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) 1978-06-06 US disclosed
US-4045438-A Cephalosporin antibiotics YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 1977-08-30 US disclosed
US-4031083-A Cephalosporin antibiotics YEDA RESEARCH AND DEVELOPMENT CO., LTD. (IL) 1977-06-21 US disclosed
US-4026887-A Cephalosporin antibiotics YEDA RESEARCH & DEVELOPMENT CO. LTD. (IL) 1977-05-31 US disclosed
US-3994875-A CEPHALOSPORINS, PENICILLINS YEDA RESEARCH & DEVELOPMENT CO. LTD. (IL) 1976-11-30 US disclosed
US-3948904-A ANTIBIOTICS YEDA RESEARCH & DEVELOPMENT CO. LTD. (IL) 1976-04-06 US disclosed