Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.50 |
| ▸ | TACR2 | P21452 | 1/20 | 0.49 |
| ▸ | TACR1 | P25103 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11367275 | 0.93 | SIGMAR1 (0.50) | SIGMAR1OPRM1KCNH2TACR2TACR1 | |
| SCHEMBL11368838 | 0.90 | SIGMAR1 (0.52) | SIGMAR1OPRM1KCNH2TACR2TACR1 | |
| SCHEMBL11359522 | 0.89 | SIGMAR1 (0.62) | SIGMAR1OPRM1KCNH2TACR2TACR1 | |
| SCHEMBL11367088 | 0.84 | SIGMAR1 (0.56) | SIGMAR1OPRM1KCNH2DRD2GRIN2D | |
| SCHEMBL20504482 | 0.82 | SIGMAR1 (0.60) | SIGMAR1OPRM1KCNH2DRD2GRIN2D | |
| SCHEMBL13078736 | 0.82 | TACR2 (0.53) | SIGMAR1OPRM1KCNH2TACR2TACR1 | |
| SCHEMBL8813523 | 0.79 | SIGMAR1 (0.51) | SIGMAR1OPRM1KCNH2POLBDRD2 | |
| SCHEMBL11367511 | 0.79 | SIGMAR1 (0.53) | SIGMAR1OPRM1KCNH2ALDH1A1DRD2 | |
| SCHEMBL3216158 | 0.78 | KMT2A (0.49) | SIGMAR1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL11359525 | 0.78 | SIGMAR1 (0.56) | SIGMAR1OPRM1KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4255432-A | ANTIHYPERTENSIVE AGENTS, ANTIHISTAMINES, BRONCHODILATOR AGENTS, ANTIVASOSPASTIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1981-03-10 | — | — | US | disclosed |
| US-4244961-A | 1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents | SYNTEX (U.S.A.) INC. (US) | 1981-01-13 | — | — | US | disclosed |