Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11364579 | 0.89 | ATM (0.50) | ATMCYP1A2HSD17B10ALDH1A1KDM4E | |
| SCHEMBL11362047 | 0.88 | CYP1A2 (0.50) | ATMCYP1A2HSD17B10ALDH1A1KDM4E | |
| SCHEMBL16760621 | 0.82 | ALDH1A1 (0.49) | ATMHSD17B10ALDH1A1KDM4ETSHR | |
| SCHEMBL16760639 | 0.80 | ALDH1A1 (0.47) | ATMALDH1A1KDM4E | |
| SCHEMBL2525409 | 0.80 | HSD17B10 (0.48) | ATMCYP1A2HSD17B10 | |
| SCHEMBL11358485 | 0.78 | HSD17B10 (0.47) | CYP1A2HSD17B10TSHRCA1CA2 | |
| SCHEMBL11363508 | 0.78 | HSD17B10 (0.47) | CYP1A2HSD17B10ALDH1A1DRD4 | |
| SCHEMBL18209306 | 0.78 | HSD17B10 (0.47) | CYP1A2HSD17B10 | |
| SCHEMBL18215447 | 0.78 | HSD17B10 (0.47) | CYP1A2HSD17B10 | |
| SCHEMBL11352479 | 0.77 | CYP1A2 (0.50) | ATMCYP1A2HSD17B10ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4244966-A | 1,3-Dihydro-3-(2-hydroxy-, 2-bromo- or 2-chloroethyl)-2H-isoindol-1-one derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1981-01-13 | — | — | US | disclosed |