Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11371054 | 0.92 | MAPT (0.54) | MEN1KMT2AMAPTTP53POLB | |
| SCHEMBL11378275 | 0.90 | NPSR1 (0.60) | MEN1KMT2AABCB1MAPTTP53 | |
| SCHEMBL11370596 | 0.87 | KDM4E (0.67) | MEN1KMT2AABCB1MAPTPOLB | |
| SCHEMBL11369447 | 0.86 | MAPT (0.50) | MEN1KMT2AMAPTSMN1; SMN2KDM4E | |
| SCHEMBL11364906 | 0.86 | CYP3A4 (0.62) | MEN1KMT2AABCB1MAPTTP53 | |
| SCHEMBL11372226 | 0.85 | TP53 (0.71) | MEN1KMT2AABCB1MAPTTP53 | |
| SCHEMBL4863792 | 0.82 | POLB (0.55) | MEN1KMT2AABCB1MAPTTP53 | |
| SCHEMBL11371377 | 0.82 | MAPT (0.56) | MEN1KMT2AABCB1MAPTTP53 | |
| SCHEMBL11377484 | 0.80 | USP2 (0.77) | MEN1KMT2AABCB1MAPTPOLB | |
| SCHEMBL4859389 | 0.79 | CYP3A4 (0.52) | MEN1KMT2AABCB1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4269838-A | ADRENERGIC BLOCKING AGENTS; ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS | NIPPON SHINYAKU CO. LTD. (JP) | 1981-05-26 | — | — | US | claimed |