Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11377484 | 0.90 | USP2 (0.77) | KDM4EPOLBMEN1KMT2AMAPT | |
| SCHEMBL11362587 | 0.88 | MAPT (0.60) | KDM4EPOLBMEN1KMT2AMAPT | |
| SCHEMBL11372226 | 0.88 | TP53 (0.71) | KDM4EPOLBMEN1KMT2AMAPT | |
| SCHEMBL11371054 | 0.88 | MAPT (0.54) | KDM4EPOLBMEN1KMT2AMAPT | |
| SCHEMBL4578208 | 0.88 | KDM4E (0.85) | KDM4EPOLBMEN1KMT2AMAPT | |
| SCHEMBL11370338 | 0.87 | KCNH2 (0.68) | KDM4EKMT2AMAPTMAPK1GLA | |
| SCHEMBL11367331 | 0.87 | MEN1 (0.54) | KDM4EPOLBMEN1KMT2AMAPT | |
| SCHEMBL11378959 | 0.87 | L3MBTL1 (0.74) | KDM4EPOLBMEN1KMT2AMAPT | |
| SCHEMBL11368552 | 0.86 | KMT2A (0.70) | KDM4EPOLBMEN1KMT2AMAPT | |
| SCHEMBL11365440 | 0.84 | TSHR (0.70) | KDM4EPOLBMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4269838-A | ADRENERGIC BLOCKING AGENTS; ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS | NIPPON SHINYAKU CO. LTD. (JP) | 1981-05-26 | — | — | US | claimed |
| US-4269838-A | ADRENERGIC BLOCKING AGENTS; ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS | NIPPON SHINYAKU CO. LTD. (JP) | 1981-05-26 | — | — | US | disclosed |