Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | DTYMK | P23919 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1883040 | 0.85 | MAPT (0.49) | BACE1MAPTCYP3A4BLMPMP22 | |
| SCHEMBL267752 | 0.83 | DTYMK (0.64) | BACE1ALDH1A1KMT2ADTYMKNPSR1 | |
| SCHEMBL31283743 | 0.83 | DTYMK (0.64) | BACE1ALDH1A1KMT2ADTYMKNPSR1 | |
| SCHEMBL28134449 | 0.83 | DTYMK (0.64) | BACE1ALDH1A1KMT2ADTYMKNPSR1 | |
| SCHEMBL6397059 | 0.81 | BACE1 (0.49) | BACE1ALDH1A1DTYMKNPSR1RXFP1 | |
| SCHEMBL8994310 | 0.81 | TDP1 (0.58) | MAPTCYP3A4BLMPMP22ALDH1A1 | |
| SCHEMBL6553684 | 0.81 | PARP1 (0.62) | MAPTCYP3A4BLMPMP22ALDH1A1 | |
| SCHEMBL10831554 | 0.81 | DTYMK (0.62) | BACE1ALDH1A1KMT2ADTYMKNPSR1 | |
| SCHEMBL4456465 | 0.81 | MAPT (0.52) | BACE1MAPTCYP3A4ALDH1A1DTYMK | |
| SCHEMBL6397073 | 0.81 | DTYMK (0.62) | BACE1ALDH1A1KMT2ADTYMKNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2604260-B1 | NOVEL HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | SHIONOGI & CO (JP) | 2017-05-10 | — | — | EP | disclosed |
| EP-2604260-A1 | NOVEL HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | Shionogi&Co., Ltd. (JP) | 2013-06-19 | — | — | EP | disclosed |
| EP-0003416-B1 | DIPHENYL ETHER COMPOUNDS USEFUL AS HERBICIDES; METHODS OF USING THEM, PROCESSES FOR PREPARING THEM, AND HERBICIDAL COMPOSITIONS CONTAINING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-08-26 | — | — | EP | disclosed |
| US-4285723-A | DERIVATIVES OF 3-PHENOXY-SULFONYLBENZAMIDE; NONPHYTOTOXIC PRE- AND POSTEMERGENCE HERBICIDES; CROPS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-08-25 | — | — | US | disclosed |
| US-4205173-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | disclosed |
| EP-0003416-A1 | Diphenyl ether compounds useful as herbicides; methods of using them, processes for preparing them, and herbicidal compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-08-08 | — | — | EP | disclosed |
| US-4060526-A | 1-Heterocyclic alkyl-1,2,3,4-tetrahydroquinazolinones and analgesic intermediates thereof | PENNWALT CORPORATION (US) | 1977-11-29 | — | — | US | disclosed |