Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amphetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 3/20 | 0.76 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.76 |
| ▸ | TAAR1 | Q96RJ0 | 5/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.76 |
| ▸ | MAOA | P21397 | 1/20 | 0.76 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.76 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.76 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.76 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.76 |
| ▸ | LAP3 | P28838 | 5/20 | 0.63 |
| ▸ | ANPEP | P15144 | 2/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | ALPI | P09923 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | XIAP | P98170 | 1/20 | 0.52 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dextroamphetamine SCHEMBL547496 | 1.00 | TAAR1 (0.76) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Levamfetamine SCHEMBL31637605 | 0.94 | TAAR1 (0.73) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL16858761 | 0.94 | TAAR1 (0.73) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Dextroamphetamine SCHEMBL17924971 | 0.94 | TAAR1 (0.73) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL10600513 | 0.90 | TAAR1 (0.61) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL4382899 | 0.89 | LAP3 (0.66) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL28990193 | 0.87 | TAAR1 (0.91) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL13747801 | 0.87 | SLC6A2 (1.00) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Dextroamphetamine SCHEMBL8859 | 0.87 | SLC6A2 (1.00) | TAAR1SLC6A2SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL1560962 | 0.87 | SLC6A2 (1.00) | TAAR1SLC6A2SLC6A4MAOASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2318 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026086030-A1 | METHOD FOR CONSTRUCTING CHIRALITY OF PYRAN RING IN ORFORGLIPRON BY MEANS OF ENZYMATIC CATALYSIS | 成都安迈博生物医药有限公司 | 2026-04-30 | — | — | WO | claimed |
| US-12570539-B2 | Systems and methods for generating radionuclides | PERSPECTIVE THERAPEUTICS, INC. (US) | 2026-03-10 | — | — | US | claimed |
| US-20260008686-A1 | SYSTEMS AND METHODS FOR GENERATING RADIONUCLIDES | PERSPECTIVE THERAPEUTICS INC (US) | 2026-01-08 | — | — | US | claimed |
| US-20250388564-A1 | METHODS OF MANUFACTURING PYRIDAZINONE COMPOUNDS | EDGEWISE THERAPEUTICS INC (US) | 2025-12-25 | — | — | US | claimed |
| US-20250368525-A1 | SYSTEMS AND METHODS FOR GENERATING RADIONUCLIDES | PERSPECTIVE THERAPEUTICS INC (US) | 2025-12-04 | — | — | US | claimed |
| US-20250372274-A1 | SYSTEMS AND METHODS FOR GENERATING RADIONUCLIDES | PERSPECTIVE THERAPEUTICS INC (US) | 2025-12-04 | — | — | US | claimed |
| US-20250270230-A1 | NOVEL SYNTHETIC STEPS FOR THE MANUFACTURING METHOD OF THE PDE4B-INHIBITOR 1-({(5R)-2-[4-(5-CHLOROPYRIMIDINE-2-YL)PIPERIDINE-1-YL]-5-OXIDO-6,7-DIHYDROTHIENO[3,2-D]PYRIMIDINE-4-YL}AMINO)CYCLOBUTYL]METHANOL | BOEHRINGER INGELHEIM INT (DE) | 2025-08-28 | — | — | US | claimed |
| WO-2025131986-A1 | NOVEL SYNTHETIC STEPS FOR THE MANUFACTURING METHOD OF THE PDE4B-INHIBITOR 1-({(5R)-2-[4-(5-CHLOROPYRIMIDINE-2-YL)PIPERIDINE-1-YL]-5-OXIDO-6,7-DIHYDROTHIENO[3,2-D]PYRIMIDINE-4-YL}AMINO)CYCLOBUTYL]METHANOL | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2025-06-26 | — | — | WO | claimed |
| EP-4568984-A1 | PROCESS FOR MANUFACTURING AN ANTIBIOTIC MACROCYCLIC PEPTIDE | F. Hoffmann-La Roche AG (CH) | 2025-06-18 | — | — | EP | claimed |
| EP-4568784-A2 | SYSTEMS AND METHODS FOR GENERATING RADIONUCLIDES | Perspective Therapeutics, Inc. (US) | 2025-06-18 | — | — | EP | claimed |
| US-20030194439-A1 | Pharmaceutical dosage form for pulsatile delivery of methylphenidate | MIDHA KAMAL K (BM) | 2003-10-16 | — | — | US | claimed |
| US-6555136-B2 | First, second and optionally third dosage units, with each dosage unit having a different drug release profile. | PHARMAQUEST, LTD. (BM) | 2003-04-29 | — | — | US | claimed |
| WO-2002059089-A2 | PROCESS FOR THE PREPARATION OF HETEROCYCLIC INDENE ANALOGS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-08-01 | — | — | WO | claimed |
| US-20020058061-A1 | Pharmaceutical dosage form for pulsatile delivery of methylphenidate | MIDHA KAMAL K (CA) | 2002-05-16 | — | — | US | claimed |
| EP-1191924-A1 | PHARMACEUTICAL DOSAGE FORM FOR PULSATILE DELIVERY OF (D-THREO)-METHYLPHENIDATE AND A SECOND CNS STIMULANT | Pharmaquest Limited (BM) | 2002-04-03 | — | — | EP | claimed |
| EP-1165054-A1 | PHARMACEUTICAL DOSAGE FORM FOR PULSATILE DELIVERY OF METHYLPHENIDATE | Pharmaquest Limited (BM) | 2002-01-02 | — | — | EP | claimed |
| US-6217904-B1 | MIXTURES; ADMINISTERING IN CYCLES | PHARMAQUEST LTD. (BM) | 2001-04-17 | — | — | US | claimed |
| WO-2000059481-A1 | PHARMACEUTICAL DOSAGE FORM FOR PULSATILE DELIVERY OF d-threo-METHYLPHENIDATE AND A SECOND CNS STIMULANT | PHARMAQUEST LTD. (BM) | 2000-10-12 | — | — | WO | claimed |
| WO-2000059479-A1 | PHARMACEUTICAL DOSAGE FORM FOR PULSATILE DELIVERY OF METHYLPHENIDATE | PHARMAQUEST LTD. (BM) | 2000-10-12 | — | — | WO | claimed |
| EP-0355825-A2 | Viral treatment system | Prendergast, Patrick T. (IE) | 1990-02-28 | — | — | EP | claimed |